BRENDA - Enzyme Database show
show all sequences of 1.14.13.29

Malaria downmodulates mRNA expression and catalytic activities of CYP1A2, 2E1 and 3A11 in mouse liver

Carvalho, R.S.; Friedrich, K.; De-Oliveira, A.C.; Suarez-Kurtz, G.; Paumgartten, F.J.; Eur. J. Pharmacol. 616, 265-269 (2009)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
malaria decreases the activity of p-nitrophenol-hydroxylase in liver microsomes by 33%, mRNA levels are lowered compared to uninfected mice
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Mus musculus
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
p-nitrophenol + NADH + H+ + O2
Mus musculus
-
p-nitrocatechol + NAD+ + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
male Swiss Webster mice infected by malaria pathogen Plasmodium berghei ANKA
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Mus musculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.00275
-
malaria infected mouse, real time kinetic method
Mus musculus
0.00411
-
mouse without infection, real time kinetic method
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
p-nitrophenol + NADH + H+ + O2
-
697776
Mus musculus
p-nitrocatechol + NAD+ + H2O
-
-
-
?
Application (protein specific)
Application
Commentary
Organism
medicine
malaria decreases the activity of p-nitrophenol-hydroxylase in liver microsomes by 33%, mRNA levels are lowered compared to uninfected mice
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Mus musculus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
p-nitrophenol + NADH + H+ + O2
Mus musculus
-
p-nitrocatechol + NAD+ + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.00275
-
malaria infected mouse, real time kinetic method
Mus musculus
0.00411
-
mouse without infection, real time kinetic method
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
p-nitrophenol + NADH + H+ + O2
-
697776
Mus musculus
p-nitrocatechol + NAD+ + H2O
-
-
-
?
Other publictions for EC 1.14.13.29
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Kallubai
In silico approach to support ...
Arthrobacter sp. JS443
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7
157-167
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745126
Kallubai
In silico approach to support ...
Arthrobacter sp., Lysinibacillus sphaericus, Lysinibacillus sphaericus JS905
Interdiscip. Sci. Comput. Life Sci.
7
157-167
2015
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7
7
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741687
Min
The gene cluster for para-nit ...
Rhodococcus imtechensis, Rhodococcus imtechensis RKJ300
Appl. Environ. Microbiol.
80
6212-6222
2014
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725938
Wagner
In vitro inhibition of 7-ethox ...
Cyprinus carpio, Salmo salar
Mol. Biol. Rep.
40
457-462
2013
-
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2
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2
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695586
Zamaratskaia
Modulation of porcine cytochro ...
Sus scrofa
Animal
3
1124-1132
2009
-
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-
-
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1
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1
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1
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697776
Carvalho
Malaria downmodulates mRNA exp ...
Mus musculus
Eur. J. Pharmacol.
616
265-269
2009
-
1
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4
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698597
Takeo
Mechanism of 4-nitrophenol oxi ...
Rhodococcus sp. PN1
J. Bacteriol.
190
7367-7374
2008
2
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1
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1
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1
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684593
Pakala
Biodegradation of methyl parat ...
Serratia sp. DS001
Appl. Microbiol. Biotechnol.
73
1452-1462
2007
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1
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673929
Vences-Mejia
The effect of aspartame on rat ...
Rattus norvegicus
Hum. Exp. Toxicol.
25
453-459
2006
1
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5
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2
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1
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1
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438907
Hanioka
Effect of alachlor on hepatic ...
Rattus norvegicus
Drug Chem. Toxicol.
25
25-37
2002
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438906
Allis
A kinetic assay for p-nitrophe ...
Rattus norvegicus
Anal. Biochem.
219
49-52
1994
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438908
Tassaneeyakul
Validation of 4-nitrophenol as ...
Homo sapiens
Biochem. Pharmacol.
46
1975-1981
1993
1
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438904
Arinc
Lung microsomal p-nitrophenol ...
Ovis aries
Comp. Biochem. Physiol. B
97
455-460
1990
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438903
Koop
Hydroxylation of p-nitrophenol ...
Oryctolagus cuniculus
Mol. Pharmacol.
29
399-404
1986
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1
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438905
Reinke
p-Nitrophenol hydroxylation. A ...
Rattus norvegicus
Drug Metab. Dispos.
13
548-552
1985
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438902
Mitra
A new 4-nitrophenol 2-hydroxyl ...
Nocardia sp.
Biochem. Int.
8
609-615
1984
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1
12
1
1
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