BRENDA - Enzyme Database
show all sequences of 1.14.13.29

Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a

Koop, D.R.; Mol. Pharmacol. 29, 399-404 (1986)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
4-nitrophenol
substrate inhibition above 0.1 mM
Oryctolagus cuniculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Oryctolagus cuniculus
-
-
Organism
Organism
UniProt
Commentary
Textmining
Oryctolagus cuniculus
-
New Zealand white male rabbit
-
Purification (Commentary)
Purification (Commentary)
Organism
-
Oryctolagus cuniculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
4-nitrophenol + NADH + O2
-
438903
Oryctolagus cuniculus
4-nitrocatechol + NAD+ + H2O
-
438903
Oryctolagus cuniculus
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.127
-
4-nitrophenol
reconstituted system of purified isozyme 3a, dilaroylglyceryl-3-phosphorylcholine and NADPH-cytochrome P-450 reductase at pH 7.6
Oryctolagus cuniculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
crude enzyme extract
Oryctolagus cuniculus
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
-
Oryctolagus cuniculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
-
Oryctolagus cuniculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-nitrophenol
substrate inhibition above 0.1 mM
Oryctolagus cuniculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Oryctolagus cuniculus
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
4-nitrophenol + NADH + O2
-
438903
Oryctolagus cuniculus
4-nitrocatechol + NAD+ + H2O
-
438903
Oryctolagus cuniculus
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.127
-
4-nitrophenol
reconstituted system of purified isozyme 3a, dilaroylglyceryl-3-phosphorylcholine and NADPH-cytochrome P-450 reductase at pH 7.6
Oryctolagus cuniculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
crude enzyme extract
Oryctolagus cuniculus
Other publictions for EC 1.14.13.29
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Kallubai
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7
157-167
2015
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745126
Kallubai
In silico approach to support ...
Arthrobacter sp., Lysinibacillus sphaericus, Lysinibacillus sphaericus JS905
Interdiscip. Sci. Comput. Life Sci.
7
157-167
2015
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8
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3
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3
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7
7
-
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741687
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Rhodococcus imtechensis, Rhodococcus imtechensis RKJ300
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2
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2
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725938
Wagner
In vitro inhibition of 7-ethox ...
Cyprinus carpio, Salmo salar
Mol. Biol. Rep.
40
457-462
2013
-
-
-
-
-
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2
-
2
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6
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3
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2
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4
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4
2
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2
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3
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695586
Zamaratskaia
Modulation of porcine cytochro ...
Sus scrofa
Animal
3
1124-1132
2009
-
-
-
-
-
-
1
-
1
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1
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3
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1
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1
3
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1
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3
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3
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1
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697776
Carvalho
Malaria downmodulates mRNA exp ...
Mus musculus
Eur. J. Pharmacol.
616
265-269
2009
-
1
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1
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1
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4
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1
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1
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1
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1
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1
2
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1
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698597
Takeo
Mechanism of 4-nitrophenol oxi ...
Rhodococcus sp. PN1
J. Bacteriol.
190
7367-7374
2008
2
-
1
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1
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3
1
1
5
-
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1
-
-
-
2
-
7
1
2
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1
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1
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2
-
1
1
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1
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3
1
1
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1
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2
-
7
1
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1
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1
1
-
-
-
684593
Pakala
Biodegradation of methyl parat ...
Serratia sp. DS001
Appl. Microbiol. Biotechnol.
73
1452-1462
2007
-
-
1
-
-
-
-
-
-
-
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1
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5
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1
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2
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2
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1
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1
1
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673929
Vences-Mejia
The effect of aspartame on rat ...
Rattus norvegicus
Hum. Exp. Toxicol.
25
453-459
2006
1
-
-
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-
-
-
-
1
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1
-
4
-
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5
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2
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3
1
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1
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1
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1
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5
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2
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1
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1
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438907
Hanioka
Effect of alachlor on hepatic ...
Rattus norvegicus
Drug Chem. Toxicol.
25
25-37
2002
-
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1
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1
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1
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438906
Allis
A kinetic assay for p-nitrophe ...
Rattus norvegicus
Anal. Biochem.
219
49-52
1994
-
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1
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1
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2
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2
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1
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1
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1
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1
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1
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2
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1
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1
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1
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-
-
438908
Tassaneeyakul
Validation of 4-nitrophenol as ...
Homo sapiens
Biochem. Pharmacol.
46
1975-1981
1993
1
-
1
-
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-
9
2
1
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1
-
-
1
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1
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1
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2
-
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2
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1
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1
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9
2
2
1
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1
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1
-
1
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2
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438904
Arinc
Lung microsomal p-nitrophenol ...
Ovis aries
Comp. Biochem. Physiol. B
97
455-460
1990
-
-
-
-
-
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1
1
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2
-
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1
1
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1
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1
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1
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1
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1
1
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1
1
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1
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1
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-
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-
-
-
-
438903
Koop
Hydroxylation of p-nitrophenol ...
Oryctolagus cuniculus
Mol. Pharmacol.
29
399-404
1986
-
-
-
-
-
-
1
-
1
-
-
-
-
2
-
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1
-
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1
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1
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1
1
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1
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1
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1
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1
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1
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1
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1
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1
1
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438905
Reinke
p-Nitrophenol hydroxylation. A ...
Rattus norvegicus
Drug Metab. Dispos.
13
548-552
1985
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-
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1
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1
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1
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1
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-
-
-
-
-
438902
Mitra
A new 4-nitrophenol 2-hydroxyl ...
Nocardia sp.
Biochem. Int.
8
609-615
1984
-
-
-
-
-
1
12
1
1
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1
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2
4
-
-
1
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1
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3
-
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3
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1
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12
-
1
1
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2
4
-
1
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1
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