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Literature summary for 1.14.13.27 extracted from
- A unique enzyme catalyzing the formation of 4-hydroxyaniline from 4-amino-benzoic acid in Agaricus bisporus (1985), Biochem. Biophys. Res. Commun., 130, 633-639.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | severe inhibition at 1 mM | Agaricus bisporus |  |
| Fe2+ | slight inhibition at 1 mM | Agaricus bisporus | |
| Hg2+ | complete inhibition at 0.1 mM | Agaricus bisporus | |
| p-chloromercuribenzoate | complete inhibition at 0.1 mM | Agaricus bisporus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agaricus bisporus | - |
mushroom | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Agaricus bisporus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fruit body | - |
Agaricus bisporus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.5 | - |
- |
Agaricus bisporus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 10 mM potassium phosphate buffer, pH 7.0, 20% glycerol, 6 months, stable | Agaricus bisporus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-aminobenzoate + NAD(P)H + O2 | - |
Agaricus bisporus | 4-hydroxyaniline + NAD(P)+ + H2O + CO2 | - |
? | |
| 4-aminosalicylate + NAD(P)H + O2 | - |
Agaricus bisporus | 3,4-dihydroxyaniline + NAD(P)+ + H2O2 + CO2 | - |
? | |
| anthranilate + NAD(P)H + O2 | - |
Agaricus bisporus | 2-hydroxyaniline + NAD(P)+ + H2O2 + CO2 | - |
? | |
| additional information | not: aniline | Agaricus bisporus | ? | - |
? | |
| additional information | not: 4-aminobenzyl-alcohol | Agaricus bisporus | ? | - |
? | |
| additional information | not: benzoic acid | Agaricus bisporus | ? | - |
? | |
| additional information | not: salicylate | Agaricus bisporus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Agaricus bisporus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | flavoprotein | Agaricus bisporus | |
| NADH | - |
Agaricus bisporus | |
| NADPH | 68% of the activity with NADH | Agaricus bisporus | |
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Release 2023.1 (January 2023)
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