Literature summary for 1.14.13.243 extracted from

Yeager, C.M.; Bottomley, P.J.; Arp, D.J.; Hyman, M.R.
Inactivation of toluene 2-monooxygenase in Burkholderia cepacia G4 by alkynes (1999), Appl. Environ. Microbiol., 65, 632-639 .

Inhibitors

Inhibitors	Comment	Organism
1-butyne	effective inhibitor of toluene-dependent growth, presence results in the irreversible loss of toluene- and o-cresol-dependent O2 uptake activities. Presence of oxygen, supplied as H2O2, is required for inhibition by 1-butyne	Burkholderia cepacia
1-hexyne	effective inhibitor of toluene-dependent growth, presence results in the irreversible loss of toluene- and o-cresol-dependent O2 uptake activities	Burkholderia cepacia
2-hexyne	effective inhibitor of toluene-dependent growth, presence results in the irreversible loss of toluene- and o-cresol-dependent O2 uptake activities	Burkholderia cepacia
3-hexyne	effective inhibitor of toluene-dependent growth, presence results in the irreversible loss of toluene- and o-cresol-dependent O2 uptake activities	Burkholderia cepacia
Acetylene	10-50% vol/vol gas phase required for inhibition of growth on toluene	Burkholderia cepacia
additional information	alkynes are specific, mechanism-based inactivators of toluene 2-monooxygenase, with acetylene being relatively ineffective compared to longer alkynes	Burkholderia cepacia

Organism	UniProt	Comment	Textmining
Burkholderia cepacia	Q9ANX4 and Q9ANX0 and Q9ANX3 and Q8VSV8 and Q9ANX1 and Q8VSV9	Q9ANX4 i.e. subunit tomA1, Q9ANX0 i.e. subunit tomA5, Q9ANX3 i.e. subunit TomA2, Q8VSV8 i.e. subunit TomA3, Q9ANX1 i.e. subunit TomA4, Q8VSV9 i.e. subunit TomA0	-
Burkholderia cepacia G4	Q9ANX4 and Q9ANX0 and Q9ANX3 and Q8VSV8 and Q9ANX1 and Q8VSV9	Q9ANX4 i.e. subunit tomA1, Q9ANX0 i.e. subunit tomA5, Q9ANX3 i.e. subunit TomA2, Q8VSV8 i.e. subunit TomA3, Q9ANX1 i.e. subunit TomA4, Q8VSV9 i.e. subunit TomA0	-