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Literature summary for 1.14.13.237 extracted from

  • Li, Y.; Li, R.; Sawada, Y.; Boerzhijin, S.; Kuwahara, A.; Sato, M.; Hirai, M.Y.
    Abscisic acid-mediated induction of FLAVIN-CONTAINING MONOOXYGENASE 2 leads to reduced accumulation of methylthioalkyl glucosinolates in Arabidopsis thaliana (2021), Plant Sci., 303, 110764 .
    View publication on PubMed
Search for more literature for 1.14.13.237

Cloned(Commentary)

Cloned (Comment) Organism
gene FMOGS-OX2, quantitative real-time PCR enzyme expression analysis Arabidopsis thaliana
gene FMOGS-OX4, quantitative real-time PCR enzyme expression analysis Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an omega-(methylsulfanyl)alkyl-glucosinolate + NADPH + H+ + O2 Arabidopsis thaliana
-
 an omega-(methylsulfinyl)alkyl-glucosinolate + NADP+ + H2O
-
 ?
an omega-(methylsulfanyl)alkyl-glucosinolate + NADPH + H+ + O2 Arabidopsis thaliana Col-0
-
 an omega-(methylsulfinyl)alkyl-glucosinolate + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q93Y23
-
-
Arabidopsis thaliana Q93Y23 isoform FMOGS-Ox4
-
Arabidopsis thaliana Q94K43
-
-
Arabidopsis thaliana Q94K43 isoform FMOGS-Ox2
-
Arabidopsis thaliana Col-0 Q93Y23
-
-
Arabidopsis thaliana Col-0 Q94K43
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information quantitative RT-PCR enzyme expression analysis in leaves and roots, overview Arabidopsis thaliana
-
root
-
 Arabidopsis thaliana
-
rosette leaf
-
 Arabidopsis thaliana
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seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an omega-(methylsulfanyl)alkyl-glucosinolate + NADPH + H+ + O2
-
 Arabidopsis thaliana an omega-(methylsulfinyl)alkyl-glucosinolate + NADP+ + H2O
-
 ?
an omega-(methylsulfanyl)alkyl-glucosinolate + NADPH + H+ + O2
-
 Arabidopsis thaliana Col-0 an omega-(methylsulfinyl)alkyl-glucosinolate + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase 2
-
 Arabidopsis thaliana
flavin-containing monooxygenase 4
-
 Arabidopsis thaliana
FMO2
-
 Arabidopsis thaliana
FMO4
-
 Arabidopsis thaliana
FMOGS-OX
-
 Arabidopsis thaliana
FMOGS-OX2
-
 Arabidopsis thaliana
FMOGS-OX4
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Arabidopsis thaliana
NADPH
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana expression of isoforms FMOGS-OX2 and FMOGS-OX4 is induced by glucose treatment, independent of transcription factors MYB28/29 and MYC2/3/4. Glucose-triggered upregulation of FMOGS-OX2 and FMOGS-OX4 is partially regulated by abscisic acid through the key negative regulators ABI1 and ABI2, and the positive regulator SnRK2, but not via the transcription factor ABI5 up
Arabidopsis thaliana the expression of FMOGS-OX2 and FMOGS-OX4 is induced by glucose treatment, independent of MYB28/29 and MYC2/3/4, the transcription factors that positively regulate aliphatic GSL biosynthesis. Glucose treatment of the abscisic acid (ABA)-related mutants indicated that glucose-triggered upregulation of FMOGS-OX2 and FMOGS-OX4 was partially regulated by ABA through the key negative regulators ABI1 and ABI2, and the positive regulator SnRK2, but not via the transcription factor ABI5. In wild-type plants, glucose treatment drastically reduces the accumulation of 4-methylthiobutyl (4MT) GSL, whereas a decrease in 4MT GSL is not observed in the fmogs-ox2, abi1-1, abi2-1, aba2-1, or aba3-1 mutants. This result indicates that the decreased accumulation of 4MT GSL by glucose treatment is attributed to upregulation of FMOGS-OX2 via the ABA signaling pathway. The expression of the FMOGS-OX2 and FMOGS-OX4 genes is induced by glucose treatment independent of the MYB and MYC transcription factors up

General Information

General Information Comment Organism
physiological function in wild-type plants, glucose treatment drastically reduces the accumulation of 4-methylthiobutyl glucosinolate, which is not observed in the FMOGS-Ox2 mutant Arabidopsis thaliana
physiological function the first step in side-chain modification of aliphatic GSLs is the S-oxygenation of the methylthioalkyl (MT) moiety to the methylsulfinylalkyl (MS) moiety. This reaction is catalyzed by flavin-containing monooxygenase (FMOGS-OX), which is encoded by seven genes in Arabidopsis thaliana Arabidopsis thaliana