Literature summary for 1.14.13.231 extracted from

Volkers, G.; Palm, G.J.; Weiss, M.S.; Wright, G.D.; Hinrichs, W.
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase (2011), FEBS Lett., 585, 1061-1066.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structure determinations at 2.1 A resolution of native TetX and its complexes with tetracyclines. Domain 1 exhibits the Rossmann fold responsible for binding of the coenzyme FAD through its adenosine monophosphate component, which is linked to the flavin mononucleotide containing the catalytically active isoalloxazine moiety. The second domain with an extended 7-stranded beta-sheet is positioned like a shield on top of the flavin-binding domain covered by five alpha-helices and is responsible for substrate recognition. A long C-terminal alpha-helix stabilizes the association of the two domains	Bacteroides thetaiotaomicron

Crystallization (Comment)

Organism

structure determinations at 2.1 A resolution of native TetX and its complexes with tetracyclines. Domain 1 exhibits the Rossmann fold responsible for binding of the coenzyme FAD through its adenosine monophosphate component, which is linked to the flavin mononucleotide containing the catalytically active isoalloxazine moiety. The second domain with an extended 7-stranded beta-sheet is positioned like a shield on top of the flavin-binding domain covered by five alpha-helices and is responsible for substrate recognition. A long C-terminal alpha-helix stabilizes the association of the two domains

Bacteroides thetaiotaomicron

Organism

Organism	UniProt	Comment	Textmining
Bacteroides thetaiotaomicron	Q93L51	-	-

Synonyms

Synonyms	Comment	Organism
TetX family tetracycline inactivation enzyme	-	Bacteroides thetaiotaomicron
TetX2	-	Bacteroides thetaiotaomicron

Cofactor

Cofactor	Comment	Organism	Structure
FAD	FAD is bound non-covalently in an elongated, so-called IN conformation with the adenine and isoalloxazine moieties distal to each other	Bacteroides thetaiotaomicron

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Release 2023.1 (January 2023)