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Literature summary for 1.14.13.22 extracted from

  • Hu, Y.; Wang, J.; Cen, Y.; Zheng, H.; Huang, M.; Lin, X.; Wu, Q.
    ''Top'' or ''bottom'' switches of a cyclohexanone monooxygenase controlling the enantioselectivity of the sandwiched substrate (2019), Chem. Commun. (Camb.), 55, 2198-2201 .
    View publication on PubMed
Search for more literature for 1.14.13.22

Protein Variants

Protein Variants Comment Organism
F432I mutation efficiently reverses the inherent enantiopreference of CHMO in the Baeyer-Villiger oxidation of various 4-phenylcyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration Acinetobacter sp.
F432Lm mutation efficiently reverses the inherent enantiopreference of CHMO in the Baeyer-Villiger oxidation of various 4-phenylcyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration Acinetobacter sp.
L435A mutation efficiently reverses the inherent enantiopreference of CHMO in the Baeyer-Villiger oxidation of various 4-phenylcyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration Acinetobacter sp.
L435G mutation efficiently reverses the inherent enantiopreference of CHMO in the Baeyer-Villiger oxidation of various 4-phenylcyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration Acinetobacter sp.

Organism

Organism UniProt Comment Textmining
Acinetobacter sp. P12015
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-(3-fluorophenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(3-fluorophenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
4-(3-methylphenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(3-methylphenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
4-(4-chlorophenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(4-chlorophenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
4-(4-fluorophenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(4-fluorophenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
4-(4-methoxyhenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(4-methoxyphenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
4-(4-methylphenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(4-methylphenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
4-ethylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-ethylhexano-6-lactone + NADP+ + H2O
-
 ?
4-methylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-methylhexano-6-lactone + NADP+ + H2O
-
 ?
4-pentylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-pentylhexano-6-lactone + NADP+ + H2O
-
 ?
4-phenylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-phenylhexano-6-lactone + NADP+ + H2O
-
 ?
4-propylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-propylhexano-6-lactone + NADP+ + H2O
-
 ?