Literature summary for 1.14.13.180 extracted from

Hwang, C.K.; Kim, H.S.; Hong, Y.S.; Kim, Y.H.; Hong, S.K.; Kim, S.J.; Lee, J.J.
Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin (1995), Antimicrob. Agents Chemother., 39, 1616-1060.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in doxorubicin-sensitive Streptomyces galilaeus ATCC 31133. Transformation of Streptomyces galilaeus ATCC 31133 with plasmid pMC213 containing the aklavinone 11-hydroxylase gene (dnrF) results in the production of many red pigments. A new metabolite is purified, and the position of the newly introduced hydroxyl group is determined. The result indicates that the aklavinone 11-hydroxylase gene is stably expressed in Streptomyces galilaeus ATCC 31133 and that it gives rise to a hybrid aclacinomycin A which shows highly specific in vitro cytotoxicity against leukemia and melanoma cell lines	Streptomyces peucetius

Cloned (Comment)

Organism

expression in doxorubicin-sensitive Streptomyces galilaeus ATCC 31133. Transformation of Streptomyces galilaeus ATCC 31133 with plasmid pMC213 containing the aklavinone 11-hydroxylase gene (dnrF) results in the production of many red pigments. A new metabolite is purified, and the position of the newly introduced hydroxyl group is determined. The result indicates that the aklavinone 11-hydroxylase gene is stably expressed in Streptomyces galilaeus ATCC 31133 and that it gives rise to a hybrid aclacinomycin A which shows highly specific in vitro cytotoxicity against leukemia and melanoma cell lines

Streptomyces peucetius

Organism

Organism	UniProt	Comment	Textmining
Streptomyces peucetius	-	-	-

Synonyms

Synonyms	Comment	Organism
DnrF	-	Streptomyces peucetius

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Release 2023.1 (January 2023)