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Literature summary for 1.14.13.1 extracted from

  • Bhushan, B.; Halasz, A.; Spain, J.C.; Hawari, J.
    Initial reaction(s) in biotransformation of CL-20 is catalyzed by salicylate 1-monooxygenase from Pseudomonas sp. strain ATCC 29352 (2004), Appl. Environ. Microbiol., 70, 4040-4047.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
O2 inhibits biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane Pseudomonas sp.

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
ATCC 29352
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000256
-
biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane Pseudomonas sp.
0.58
-
reaction with salicylate Pseudomonas sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane + NADH the enzyme catalyzes two oxygen-sensitive single-electron transfer steps necessary to release two nitrite ions from 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane and this is followed by the secondary decomposition of this energetic chemical Pseudomonas sp. NO2- + N2O + formate + NH4+ N2O is abiotically produced from NO2-NH2 ?
salicylate + NADH + H+ + O2
-
Pseudomonas sp. catechol + NAD+ + H2O + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
FAD the FAD-site of the enzyme is involved in the biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane Pseudomonas sp.
NADH
-
Pseudomonas sp.