Any feedback?
Literature summary for 1.14.12.18 extracted from
- Bacterial metabolism of polychlorinated biphenyls (2008), J. Mol. Microbiol. Biotechnol., 15, 121-138.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Paraburkholderia xenovorans LB400 | - |
- |
- |
| Pseudomonas putida | - |
- |
- |
| Pseudomonas putida KF715 | - |
- |
- |
| Rhodococcus sp. | - |
- |
- |
| Rhodococcus sp. RHA1 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biphenyl + NADH + H+ + O2 | - |
Paraburkholderia xenovorans LB400 | 2,3-dihydro-dihydroxybiphenyl + NAD+ | - |
? |  |
| additional information | biphenyl pathway of strain LB400 oxidizes an unusually wide range of polychlorinated biphenyl congeners and BphA is able to dihydroxylate from mono-chlorobiphenyls to 2,3,4,5,2',5'-hexachlorobiphenyl, is able to oxidize other substituted biphenyls, unsubstituted dibenzofuran and dibenzodioxin and is also able to transform different isoflavonoids. A hybrid BphA based on the LB400 enzyme but harboring the core segment of an oxygenase from Pseudomonas sp. strain B4-Magdeburg shows (depending on the congener considered) complementing or improved degradative properties. BphA mutants with increased catalytic turnover on polychlorinated biphenyls, that are recalcitrant for the parental BphA from strain LB400 | Paraburkholderia xenovorans LB400 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Biphenyl 2,3-dioxygenase | - |
Pseudomonas putida |
| Biphenyl 2,3-dioxygenase | - |
Rhodococcus sp. |
| Biphenyl 2,3-dioxygenase | - |
Paraburkholderia xenovorans LB400 |
| BphA | - |
Rhodococcus sp. |
| BphA | - |
Paraburkholderia xenovorans LB400 |
| BphABCD | - |
Pseudomonas putida |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Paraburkholderia xenovorans LB400 | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rhodococcus sp. | bph gene cluster bphAaAbAcAdCB is localized on the linear plasmid pRHL1, which is followed by bphS and bphT genes which encode a two-component signal transduction system composed of a BphT response regulator and a BpdS sensor kinase and promote transcriptional induction by aromatic compounds biphenyl, benzene, alkylbenzene and chlorinated benzene | up |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
