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show all sequences of 1.14.11.B1

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family

Hillringhaus, L.; Yue, W.W.; Rose, N.R.; Ng, S.S.; Gileadi, C.; Loenarz, C.; Bello, S.H.; Bray, J.E.; Schofield, C.J.; Oppermann, U.; J. Biol. Chem. 286, 41616-41625 (2011)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression of N-terminally His-tagged KDM4A in Escherichia coli; expression of N-terminally His-tagged KDM4B in Escherichia coli; expression of N-terminally His-tagged KDM4C in Escherichia coli; expression of N-terminally His-tagged KDM4D in Escherichia coli; expression of N-terminally His-tagged KDM4E in Escherichia coli
Homo sapiens
Crystallization (Commentary)
Crystallization
Organism
purified recombinant KDM4C, sitting drop vapor diffusion method, mixing of 7 mg/ml protein with 2 mM N-oxalylglycine with well solution, containing 25% v/v PEG 3350, 0.2 M sodium nitrate, 0.1 M Bis tris propane, pH 6.5, 5% v/v ethylene glycol, 0.01 M NiCl2, in a 2:1 ratio, 4°C, X-ray diffraction structure determination and analysis at 2.55 A resolution
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
I71L
KDM4E mutant, no demethylation of H3K9me2, but the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
I87K
KDM4E mutant, no demethylation of H3K9me2, but the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
N86H
KDM4E mutant, no demethylation of H3K9me2, but the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
Q88K
KDM4E mutant, the mutant shows demethylation of H3K9me2, and the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
R309G
KDM4E mutant, poor demethylation of H3K9me2, but the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.023
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
0.025
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
0.031
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
0.037
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
0.045
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
0.048
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
0.05
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
0.066
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
0.073
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
0.074
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Homo sapiens
5634
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
structure of Zn2+ binding sites of the isozymes, overview; structure of Zn2+ binding sites of the isozymes, overview; structure of Zn2+ binding sites of the isozymes, overview; structure of Zn2+ binding sites of the isozymes, overview; structure of Zn2+ binding sites of the isozymes, overview
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
?
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
?
additional information
Homo sapiens
KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates. No activity by all isozymes with H3K4me3, H3K9me1, and H3K27me3
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
B2RXH2
KDM4E
-
Homo sapiens
O75164
KDM4A; KDM4A
-
Homo sapiens
O94953
KDM4B
-
Homo sapiens
Q6B0I6
KDM4D
-
Homo sapiens
Q9H3R0
KDM4C
-
Purification (Commentary)
Commentary
Organism
recombinant N-terminally His-tagged KDM4A from Escherichia coli by nickel affinity chromatography; recombinant N-terminally His-tagged KDM4B from Escherichia coli by nickel affinity chromatography; recombinant N-terminally His-tagged KDM4C from Escherichia coli by nickel affinity chromatography; recombinant N-terminally His-tagged KDM4D from Escherichia coli by nickel affinity chromatography; recombinant N-terminally His-tagged KDM4E from Escherichia coli by nickel affinity chromatography
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
725450
Homo sapiens
histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
725450
Homo sapiens
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
additional information
KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates. No activity by all isozymes with H3K4me3, H3K9me1, and H3K27me3
725450
Homo sapiens
?
-
-
-
-
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0029
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
0.005
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
0.0072
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
0.01
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
0.012
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
0.015
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
0.028
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
0.029
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
0.065
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
0.076
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of N-terminally His-tagged KDM4A in Escherichia coli
Homo sapiens
expression of N-terminally His-tagged KDM4C in Escherichia coli
Homo sapiens
expression of N-terminally His-tagged KDM4B in Escherichia coli
Homo sapiens
expression of N-terminally His-tagged KDM4D in Escherichia coli
Homo sapiens
expression of N-terminally His-tagged KDM4E in Escherichia coli
Homo sapiens
Crystallization (Commentary) (protein specific)
Crystallization
Organism
purified recombinant KDM4C, sitting drop vapor diffusion method, mixing of 7 mg/ml protein with 2 mM N-oxalylglycine with well solution, containing 25% v/v PEG 3350, 0.2 M sodium nitrate, 0.1 M Bis tris propane, pH 6.5, 5% v/v ethylene glycol, 0.01 M NiCl2, in a 2:1 ratio, 4°C, X-ray diffraction structure determination and analysis at 2.55 A resolution
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
I71L
KDM4E mutant, no demethylation of H3K9me2, but the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
I87K
KDM4E mutant, no demethylation of H3K9me2, but the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
N86H
KDM4E mutant, no demethylation of H3K9me2, but the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
Q88K
KDM4E mutant, the mutant shows demethylation of H3K9me2, and the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
R309G
KDM4E mutant, poor demethylation of H3K9me2, but the mutant demethylates H3K9me3 to H3K9me2 and H3K9me1 in a similar manner to wild-type KDM4A
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.023
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
0.025
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
0.031
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
0.037
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
0.045
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
0.048
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
0.05
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
0.066
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
0.073
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
0.074
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Homo sapiens
5634
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
structure of Zn2+ binding sites of the isozymes, overview
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
?
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
?
additional information
Homo sapiens
KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates. No activity by all isozymes with H3K4me3, H3K9me1, and H3K27me3
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant N-terminally His-tagged KDM4A from Escherichia coli by nickel affinity chromatography
Homo sapiens
recombinant N-terminally His-tagged KDM4B from Escherichia coli by nickel affinity chromatography
Homo sapiens
recombinant N-terminally His-tagged KDM4C from Escherichia coli by nickel affinity chromatography
Homo sapiens
recombinant N-terminally His-tagged KDM4D from Escherichia coli by nickel affinity chromatography
Homo sapiens
recombinant N-terminally His-tagged KDM4E from Escherichia coli by nickel affinity chromatography
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
725450
Homo sapiens
histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
725450
Homo sapiens
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
additional information
KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates. No activity by all isozymes with H3K4me3, H3K9me1, and H3K27me3
725450
Homo sapiens
?
-
-
-
-
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0029
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
0.005
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
0.0072
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
0.01
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
0.012
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
0.015
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
0.028
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
0.029
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
0.065
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
0.076
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
General Information
General Information
Commentary
Organism
evolution
human JMJD2 (KDM4) H3K9 and H3K36 demethylases can be divided into members that act on both H3K9 and H3K36 and H3K9 alone, structural and phylogenetic analysis, overview. KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates, substrate selectivity of the human KDM4 histone demethylase subfamily, overview; human JMJD2 (KDM4) H3K9 and H3K36 demethylases can be divided into members that act on both H3K9 and H3K36 and H3K9 alone, structural and phylogenetic analysis, overview. KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates, substrate selectivity of the human KDM4 histone demethylase subfamily, overview; human JMJD2 (KDM4) H3K9 and H3K36 demethylases can be divided into members that act on both H3K9 and H3K36 and H3K9 alone, structural and phylogenetic analysis, overview. KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates, substrate selectivity of the human KDM4 histone demethylase subfamily, overview; human JMJD2 (KDM4) H3K9 and H3K36 demethylases can be divided into members that act on both H3K9 and H3K36 and H3K9 alone, structural and phylogenetic analysis, overview. KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates, substrate selectivity of the human KDM4 histone demethylase subfamily, overview; human JMJD2 (KDM4) H3K9 and H3K36 demethylases can be divided into members that act on both H3K9 and H3K36 and H3K9 alone, structural and phylogenetic analysis, overview. KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates, substrate selectivity of the human KDM4 histone demethylase subfamily, overview
Homo sapiens
additional information
substrate selectivity is determined by multiple interactions within the catalytic domain but outside the active site, structural basis of sequence celectivity between KDM4 members, overview. Ile71A, Asn86A, Ile87A, Gln88A, and Arg309A may not be required for binding of H3K9 substrate; substrate selectivity is determined by multiple interactions within the catalytic domain but outside the active site, structural basis of sequence celectivity between KDM4 members, overview. Ile71A, Asn86A, Ile87A, Gln88A, and Arg309A may not be required for binding of H3K9 substrate; substrate selectivity is determined by multiple interactions within the catalytic domain but outside the active site, structural basis of sequence celectivity between KDM4 members, overview. Ile71A, Asn86A, Ile87A, Gln88A, and Arg309A may not be required for binding of H3K9 substrate; substrate selectivity is determined by multiple interactions within the catalytic domain but outside the active site, structural basis of sequence celectivity between KDM4 members, overview. Ile71A, Asn86A, Ile87A, Gln88A, and Arg309A may not be required for binding of H3K9 substrate; substrate selectivity is determined by multiple interactions within the catalytic domain but outside the active site, structural basis of sequence celectivity between KDM4 members, overview. Ile71A, Asn86A, Ile87A, Gln88A, and Arg309A may not be required for binding of H3K9 substrate
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
evolution
human JMJD2 (KDM4) H3K9 and H3K36 demethylases can be divided into members that act on both H3K9 and H3K36 and H3K9 alone, structural and phylogenetic analysis, overview. KDM4D and -E only act on H3K9, with no evidence for demethylation of H3K36, while KDM4A/B/C act on both H3K9 and, less efficiently, on H3K36-methylated substrates, substrate selectivity of the human KDM4 histone demethylase subfamily, overview
Homo sapiens
additional information
substrate selectivity is determined by multiple interactions within the catalytic domain but outside the active site, structural basis of sequence celectivity between KDM4 members, overview. Ile71A, Asn86A, Ile87A, Gln88A, and Arg309A may not be required for binding of H3K9 substrate
Homo sapiens
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
4
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
10
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
11
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
16
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
22
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
41
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
60
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
90
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
260
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
330
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
4
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
10
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
11
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
16
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
22
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4A, pH and temperature not specified in the publication
Homo sapiens
41
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4D, pH and temperature not specified in the publication
Homo sapiens
60
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4C, pH and temperature not specified in the publication
Homo sapiens
90
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4B, pH and temperature not specified in the publication
Homo sapiens
260
-
histone H3 N6,N6-dimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
330
-
histone H3 N6,N6,N6-trimethyl-L-lysine9
KDM4E, pH and temperature not specified in the publication
Homo sapiens
Other publictions for EC 1.14.11.B1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743916
Hancock
The activity of JmjC histone ...
Homo sapiens
ACS Chem. Biol.
12
1011-1019
2017
-
1
1
-
1
-
-
4
-
-
-
1
-
1
-
-
1
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
4
-
-
-
1
-
-
-
1
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
743984
Cai
Histone demethylase JMJD1C re ...
Homo sapiens
Am. J. Cancer Res.
7
115-124
2017
-
-
1
-
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
11
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
11
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744413
Maina
Histone demethylase PHF8 regu ...
Homo sapiens
Biochim. Biophys. Acta
1860
1002-1012
2017
-
-
-
-
1
-
-
-
1
-
-
3
-
1
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744494
Amano
Development and crystallograp ...
Homo sapiens
Bioorg. Med. Chem.
25
2617-2624
2017
-
-
-
1
-
-
15
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
13
-
-
-
-
-
-
1
-
-
-
15
13
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
745030
Audonnet
JMJ24 antagonizes histone H3K ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Gene Expr. Patterns
25-26
1-7
2017
-
-
1
-
1
-
-
-
-
-
-
4
-
5
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
4
-
-
-
745752
Liu
LincRNAFEZF1-AS1 represses p2 ...
Homo sapiens
Mol. Cancer
16
39
2017
-
-
-
-
-
-
-
-
1
1
-
3
-
1
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
3
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
745771
Vyas
Lysine-specific demethylase-1 ...
Mus musculus
Mol. Cell. Neurosci.
82
1-11
2017
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745949
An
HistoneH3 demethylase JMJD2A ...
Homo sapiens
Oncotarget
8
49093-49109
2017
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745951
Qin
The histone demethylase Kdm3a ...
Mus musculus
Oncotarget
8
84761-84775
2017
1
-
-
-
1
-
-
-
1
1
-
3
-
2
-
-
-
-
-
5
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
-
5
-
-
4
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
746085
Dutta
JMJ27, an Arabidopsis H3K9 hi ...
Arabidopsis thaliana
Plant J.
91
1015-1028
2017
-
-
1
-
1
-
-
-
1
1
-
2
-
3
-
-
-
-
-
4
-
-
5
-
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
4
-
-
5
-
1
-
1
-
-
-
-
-
1
3
3
1
-
-
746217
Jang
Histone H3K9 demethylase JMJD ...
Homo sapiens
PLoS ONE
12
e0168185
2017
-
-
1
-
1
-
-
-
1
1
-
2
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
744236
Choi
KDM7A histone demethylase med ...
Homo sapiens
Biochem. Biophys. Res. Commun.
478
1355-1362
2016
-
-
1
-
1
-
-
-
2
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744347
Burg
Lysine-specific demethylase 1 ...
Homo sapiens
Biochemistry
55
1652-1662
2016
-
-
-
-
-
-
3
-
1
-
-
3
-
1
-
-
-
-
-
-
-
-
4
1
1
-
-
-
1
-
-
1
3
-
1
-
-
-
1
-
-
-
1
3
3
-
1
-
-
3
-
-
-
-
-
-
-
-
4
1
1
-
-
-
1
-
-
-
-
2
2
-
-
-
744722
Morera
4-biphenylalanine- and 3-phen ...
Homo sapiens
ChemMedChem
11
2063-2083
2016
1
-
1
-
-
-
33
1
1
1
-
3
-
2
-
-
1
1
-
2
-
-
5
-
1
-
-
-
1
-
-
-
-
-
30
1
-
1
-
-
-
-
30
33
-
1
1
1
-
3
-
-
-
1
-
2
-
-
5
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
744782
Pedanou
The histone H3K9 demethylase ...
Homo sapiens
eLife
5
e16844
2016
-
-
1
-
2
-
-
-
2
-
-
3
-
3
-
-
-
-
-
5
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
5
-
-
3
-
-
-
-
-
-
-
-
-
2
3
3
2
-
-
744785
Pedersen
Continual removal of H3K9 pro ...
Mus musculus, Mus musculus C57BL/6
EMBO J.
35
1550-1564
2016
-
-
1
-
1
-
-
-
2
-
-
10
-
5
-
-
-
-
-
1
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
4
-
-
10
-
-
-
-
-
3
-
-
10
-
-
-
-
-
-
-
-
-
2
3
9
3
-
-
745525
Bavetsias
8-Substituted pyrido[3,4-d]py ...
Homo sapiens
J. Med. Chem.
59
1388-1409
2016
-
-
1
1
1
-
64
-
1
1
-
2
-
2
-
-
1
-
-
2
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
1
-
-
123
-
-
2
2
-
2
-
-
-
1
-
4
-
-
3
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
745889
Yuan
KDM4C, a H3K9me3 histone deme ...
Homo sapiens
Neoplasia
18
594-609
2016
-
2
-
-
1
-
1
-
3
-
-
1
-
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
1
-
-
3
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
746196
Gu
The histone demethylase PHF8 ...
Homo sapiens
PLoS ONE
11
e0146645
2016
-
-
1
-
1
-
-
-
1
-
-
4
-
2
-
-
-
-
-
3
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
4
-
-
-
-
-
3
-
-
5
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
744863
Jiang
Histone H3K9 demethylase JMJD ...
Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
FASEB J.
29
1830-1841
2015
-
-
2
-
2
-
-
-
-
-
-
4
-
7
-
-
-
-
-
4
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
4
-
-
4
-
-
-
-
-
-
-
-
-
-
6
9
-
-
-
745102
Liu
The histone H3K9 demethylase ...
Mus musculus, Mus musculus C57BL/6
Int. J. Biol. Sci.
11
494-507
2015
-
-
-
-
1
-
-
-
-
-
-
6
-
3
-
-
-
-
-
4
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
4
-
-
6
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
746537
Xiao
Cadmium induces histone H3 ly ...
Homo sapiens
Toxicol. Sci.
145
80-89
2015
1
-
-
-
-
-
1
-
2
1
-
1
-
2
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
2
1
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
744188
El Mansouri
Lysine-specific demethylase 1 ...
Homo sapiens
Arthritis Res. Ther.
16
R113
2014
1
-
1
-
1
-
2
-
2
1
-
2
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
1
-
-
2
-
-
2
1
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
744224
Shen
The histone demethylase PHF8 ...
Homo sapiens
Biochem. Biophys. Res. Commun.
451
119-125
2014
-
-
1
-
1
-
-
-
1
-
-
3
-
1
-
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744861
Liu
Hairless is a histone H3K9 de ...
Homo sapiens
FASEB J.
28
1534-1542
2014
1
-
1
-
3
-
-
-
1
1
-
3
-
3
-
-
-
-
-
6
-
-
4
1
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
3
-
-
-
-
-
1
1
-
3
-
-
-
-
-
6
-
-
4
1
1
-
-
-
1
-
-
-
-
3
3
-
-
-
745917
Zoabi
RNA-dependent chromatin local ...
Homo sapiens
Nucleic Acids Res.
42
13026-13038
2014
1
-
1
-
1
-
-
1
2
1
-
1
-
1
-
-
1
-
-
1
-
-
2
-
2
-
-
-
2
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
1
2
1
-
1
-
-
-
1
-
1
-
-
2
-
2
-
-
-
2
-
-
-
-
1
1
-
-
-
745919
Kupershmit
KDM4C (GASC1) lysine demethyl ...
Homo sapiens
Nucleic Acids Res.
42
6168-6182
2014
-
-
1
-
3
-
-
-
2
-
-
4
-
4
-
-
-
-
-
4
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
4
-
-
-
-
-
4
-
-
4
-
-
-
-
-
16
-
-
4
4
-
-
-
-
-
-
-
-
-
3
12
-
-
-
745939
Tee
The histone demethylase JMJD1 ...
Homo sapiens
Oncotarget
5
1793-1804
2014
-
1
-
-
-
-
2
-
1
-
-
1
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
2
-
-
1
-
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
2
2
2
2
-
-
725520
Ipenberg
Heat shock protein 90 (Hsp90) ...
Homo sapiens
J. Biol. Chem.
288
14681-14687
2013
-
-
1
-
-
1
1
-
1
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
726050
Das
Functional analysis of histone ...
Mus musculus
Neurotox. Res.
23
154-165
2013
-
-
1
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
718758
Janzer
Lysine-specific demethylase 1 ...
Homo sapiens
Biochem. Biophys. Res. Commun.
421
665-670
2012
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
724485
Gupta
Histone H3 lysine 4 monomethyl ...
Mus musculus
Biochimie
94
2656-2664
2012
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
712775
Bartova
Mutant genetic background affe ...
Mus musculus
J. Mol. Biol.
405
679-695
2011
-
-
1
-
1
-
1
-
3
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
3
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
724184
Li
Histone demethylase JMJD2B is ...
Homo sapiens
Biochem. Biophys. Res. Commun.
416
372-378
2011
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
724316
Luka
Histone demethylase LSD1 is a ...
Homo sapiens
Biochemistry
50
4750-4756
2011
2
-
-
-
-
-
-
-
1
-
2
2
-
1
-
-
1
-
-
1
-
-
2
1
1
-
-
-
1
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
-
1
-
2
2
-
-
-
1
-
1
-
-
2
1
1
-
-
-
1
-
-
-
-
2
2
-
-
-
724503
Iwamori
The testis-enriched histone de ...
Mus musculus
Biol. Reprod.
84
1225-1234
2011
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
724694
Toyokawa
The histone demethylase JMJD2B ...
Homo sapiens
Cancer Prev. Res. (Phila)
4
2051-2061
2011
-
1
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
725450
Hillringhaus
Structural and evolutionary ba ...
Homo sapiens
J. Biol. Chem.
286
41616-41625
2011
-
-
1
1
5
-
-
10
1
1
-
15
-
5
-
-
1
-
-
-
-
-
15
-
-
-
-
10
-
-
-
-
-
-
-
-
-
5
-
1
5
-
-
-
-
10
5
5
-
15
-
-
-
5
-
-
-
-
15
-
-
-
-
10
-
-
-
-
-
2
10
-
10
10
726259
Verrier
A new isoform of the histone d ...
Homo sapiens
PLoS Genet.
7
e1001390
2011
-
-
1
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
726380
Shi
Histone demethylase JMJD2B coo ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
108
7541-7546
2011
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
711677
Yang
The histone demethylase JMJD2B ...
Homo sapiens
Cancer Res.
70
6456-6466
2010
-
1
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
711703
Suganuma
Features of the PHF8/KIAA1718 ...
Caenorhabditis elegans, Homo sapiens
Cell Res.
20
861-862
2010
-
-
-
2
-
-
-
-
-
1
-
4
-
2
-
-
-
-
-
-
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711823
Strobl-Mazzulla
Histone demethylase JmjD2A reg ...
Gallus gallus
Dev. Cell
19
460-468
2010
-
-
1
-
1
-
-
-
1
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
696340
Gaweska
Use of pH and kinetic isotope ...
Homo sapiens
Biochemistry
48
5440-5445
2009
-
-
1
-
1
-
-
3
-
-
-
1
-
1
-
1
1
-
-
-
-
-
3
-
1
-
-
1
1
1
1
1
-
-
-
-
-
1
1
-
1
-
-
-
-
3
-
-
-
1
-
-
1
1
-
-
-
-
3
-
1
-
-
1
1
1
1
-
-
-
-
-
-
-
696434
Marmorstein
Histone modifying enzymes: str ...
Homo sapiens
Biochim. Biophys. Acta
1789
58-68
2009
-
-
-
1
1
-
1
-
-
-
-
5
-
1
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
1
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697002
Kavi
Drosophila KDM2 is a H3K4me3 d ...
Drosophila melanogaster
BMC Res. Notes
2
217
2009
-
-
-
-
1
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
697107
Schulte
Lysine-specific demethylase 1 ...
Homo sapiens
Cancer Res.
69
2065-2071
2009
-
-
1
-
1
-
2
-
-
-
-
5
-
1
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
-
-
-
-
5
-
-
-
-
-
2
-
-
6
-
-
-
-
-
-
-
-
-
1
3
3
1
-
-
697241
Katz
A C. elegans LSD1 demethylase ...
Caenorhabditis elegans
Cell
137
308-320
2009
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
697546
Nottke
Developmental roles of the his ...
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Development
136
879-889
2009
7
-
-
-
3
-
8
-
7
7
-
25
-
7
-
-
-
-
-
10
-
-
45
2
-
-
-
-
-
-
-
7
-
-
-
7
-
-
7
-
3
-
-
8
-
-
7
7
-
25
-
-
-
-
-
10
-
-
45
2
-
-
-
-
-
-
-
-
2
7
7
2
-
-
697557
Brasacchio
Hyperglycemia induces a dynami ...
Homo sapiens, Mus musculus
Diabetes
58
1229-1236
2009
2
-
-
-
-
-
-
-
2
-
-
4
-
3
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
697672
Nicholson
LSD1 demethylates histone and ...
Mammalia
Epigenetics
4
129-132
2009
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
697909
Forneris
New roles of flavoproteins in ...
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens
FEBS J.
276
4304-4312
2009
1
-
-
1
1
-
-
-
1
-
-
9
-
7
-
-
-
-
-
-
-
-
13
1
-
-
-
-
-
-
-
4
-
-
-
1
-
-
4
1
1
-
-
-
-
-
1
-
-
9
-
-
-
-
-
-
-
-
13
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
698098
Lorbeck
The histone demethylase DmelKd ...
Drosophila melanogaster
Gene
450
8-17
2009
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
698198
Magerl
H3K4 dimethylation in hepatoce ...
Homo sapiens
Hum. Pathol.
41
181-189
2009
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
7
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
7
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698910
Karytinos
A novel mammalian flavin-depen ...
Mus musculus
J. Biol. Chem.
284
17775-17782
2009
-
-
1
-
1
-
6
8
-
-
-
-
-
1
-
-
1
-
-
-
-
-
9
-
1
-
-
8
1
-
-
1
6
-
-
-
-
1
1
-
1
-
-
6
6
8
-
-
-
-
-
-
-
1
-
-
-
-
9
-
1
-
-
8
1
-
-
-
-
-
-
-
-
-
700164
Lee
The H3K4 demethylase lid assoc ...
Drosophila melanogaster
Mol. Cell. Biol.
29
1401-1410
2009
1
-
1
-
-
-
-
-
1
1
-
2
-
2
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
2
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
700361
Wang
The lysine demethylase LSD1 (K ...
Mus musculus
Nat. Genet.
41
125-129
2009
-
-
1
-
2
-
1
-
-
-
-
3
-
2
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
1
-
-
-
-
-
3
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
700397
Ciccone
KDM1B is a histone H3K4 demeth ...
Mus musculus
Nature
461
415-418
2009
-
-
1
-
2
-
-
-
1
-
-
3
-
3
-
-
1
-
-
4
-
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
3
-
-
-
1
-
4
-
-
6
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
700991
Hu
LSD1-mediated epigenetic modif ...
Mus musculus
Proc. Natl. Acad. Sci. USA
106
10141-10146
2009
-
-
-
-
1
-
1
-
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-
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-
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1
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2
-
-
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-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
2
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
701212
Lan
Epigenetic regulation: methyla ...
Drosophila melanogaster
Sci. China C Life Sci.
52
311-322
2009
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
710874
Yang
Role of hypoxia-inducible fact ...
Homo sapiens
Ann. N. Y. Acad. Sci.
1177
185-197
2009
-
-
-
-
1
-
1
-
2
-
-
1
-
1
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
-
1
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
1
3
3
1
-
-
711769
Huang
Novel oligoamine analogues inh ...
Homo sapiens
Clin. Cancer Res.
15
7217-7228
2009
-
-
-
-
-
-
13
-
-
-
-
1
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
13
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
713088
Liang
Inhibition of the histone deme ...
Homo sapiens
Nat. Med.
15
1312-1317
2009
-
-
-
-
-
-
2
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
684888
Mimasu
Crystal structure of histone d ...
Homo sapiens
Biochem. Biophys. Res. Commun.
366
15-22
2008
-
-
1
1
-
-
2
-
1
-
-
2
-
1
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
2
-
-
1
-
-
2
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
684929
Wellmann
Hypoxia upregulates the histon ...
Homo sapiens, Rattus norvegicus
Biochem. Biophys. Res. Commun.
372
892-897
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689255
Lloret-Llinares
Characterization of Drosophila ...
Drosophila melanogaster
Nucleic Acids Res.
36
2852-2863
2008
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689713
Zhu
Lysine-specific demethylase 1 ...
Homo sapiens
PLoS ONE
3
e1446
2008
-
-
-
-
1
-
1
-
-
-
-
2
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690008
Seneda
Developmental regulation of hi ...
Sus scrofa
Reproduction
135
829-838
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
696261
Spedaletti
Characterization of a lysine-s ...
Arabidopsis thaliana
Biochemistry
47
4936-4947
2008
1
-
1
-
-
-
4
2
1
-
-
2
-
4
-
1
1
-
-
6
-
-
3
1
1
-
-
2
1
1
-
1
-
-
-
1
-
1
1
-
-
-
-
4
-
2
1
-
-
2
-
-
1
1
-
6
-
-
3
1
1
-
-
2
1
1
-
-
-
-
-
-
-
-
697355
Reddy
Role of the lysine-specific de ...
Mus musculus
Circ. Res.
103
615-623
2008
-
-
-
-
1
-
-
-
-
-
-
1
-
4
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
697517
Lan
Mechanisms involved in the reg ...
Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
Curr. Opin. Cell Biol.
20
316-325
2008
-
-
-
-
-
-
-
-
-
-
-
12
-
4
-
-
-
-
-
36
-
-
21
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
36
-
-
21
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
698105
Pasini
Coordinated regulation of tran ...
Mus musculus
Genes Dev.
22
1345-1355
2008
-
-
-
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
698354
Cui
Histone lysine methyltransfera ...
Plasmodium falciparum
Int. J. Parasitol.
38
1083-1097
2008
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
699898
Chau
Cell cycle association of the ...
Homo sapiens
J. Virol.
82
3428-3437
2008
-
-
1
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700154
Yokoyama
Transrepressive function of TL ...
Homo sapiens
Mol. Cell. Biol.
28
3995-4003
2008
-
-
-
-
2
-
-
-
-
-
-
2
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
700158
Tsai
p53-targeted LSD1 functions in ...
Mus musculus
Mol. Cell. Biol.
28
5139-5146
2008
-
-
1
-
1
-
1
-
1
-
-
2
-
3
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
700159
Dey
The histone demethylase KDM5b/ ...
Mus musculus
Mol. Cell. Biol.
28
5312-5327
2008
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
700201
Lopez-Bigas
Genome-wide analysis of the H3 ...
Homo sapiens
Mol. Cell
31
520-530
2008
-
-
1
-
-
-
-
-
2
-
-
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
700373
Lee
Distinct binding modes specify ...
Homo sapiens
Nat. Struct. Mol. Biol.
15
109-111
2008
-
-
-
1
8
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
8
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701350
Forneris
LSD1: oxidative chemistry for ...
Drosophila melanogaster, Homo sapiens
Trends Biochem. Sci.
33
181-189
2008
-
1
-
-
-
-
5
-
-
-
-
6
-
2
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
5
-
-
-
-
-
6
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
686952
Loh
Jmjd1a and Jmjd2c histone H3 L ...
Mus musculus
Genes Dev.
21
2545-2557
2007
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689144
Couture
Specificity and mechanism of J ...
Homo sapiens
Nat. Struct. Mol. Biol.
14
689-695
2007
-
-
1
1
1
-
-
7
-
1
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
7
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
7
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
689151
Ng
Crystal structures of histone ...
Homo sapiens
Nature
448
87-91
2007
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689154
Okada
Histone demethylase JHDM2A is ...
Mus musculus
Nature
450
119-123
2007
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689709
Opel
Genome-wide studies of histone ...
Schizosaccharomyces pombe
PLoS ONE
2
e386
2007
-
-
1
-
1
-
-
-
-
-
-
1
-
2
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668236
Lee
Histone H3 lysine 4 demethylat ...
Mus musculus
Chem. Biol.
13
563-567
2006
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669052
Culhane
A Mechanism-based inactivator ...
Homo sapiens
J. Am. Chem. Soc.
128
4536-4537
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670250
Lee
Functional interplay between h ...
Homo sapiens
Mol. Cell. Biol.
26
6395-6402
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670693
Chen
Crystal structure of human his ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
103
13956-13961
2006
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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668605
Forneris
Histone demethylation catalyse ...
Homo sapiens
FEBS Lett.
579
2203-2207
2005
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