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Literature summary for 1.14.11.80 extracted from

  • Minor, E.A.; Court, B.L.; Young, J.I.; Wang, G.
    Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine (2013), J. Biol. Chem., 288, 13669-13674.
    View publication on PubMed
Search for more literature for 1.14.11.80

Activating Compound

Activating Compound Comment Organism Structure
ascorbate ascorbate (0.0001-1 mM) significantly and specifically enhances enzyme-mediated generation of 5-hydroxymethylcytosine to 4fold above basal levels Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
phloretin
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-methylcytosine in DNA + 2-oxoglutarate + O2 Mus musculus
-
 5-hydroxymethylcytosine in DNA + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BG87
-
-
Mus musculus Q3URK3
-
-
Mus musculus Q4JK59
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-methylcytosine in DNA + 2-oxoglutarate + O2
-
 Mus musculus 5-hydroxymethylcytosine in DNA + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
Ten-eleven translocation
-
 Mus musculus
Tet methylcytosine dioxygenase
-
 Mus musculus
TET1 isoform Mus musculus
TET2 isoform Mus musculus
TET3 isoform Mus musculus

Cofactor

Cofactor Comment Organism Structure
2-oxoglutarate
-
 Mus musculus
ascorbate
-
 Mus musculus