Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N371 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
JMJD5 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | JMJD5 has divalent cation-dependent protease activities that preferentially cleave the tails of histones 2, 3, or 4 containing methylated arginines, e.g. reaction of EC 1.14.11.27. After the initial specific cleavage, JMJD5 acting as aminopeptidase, progressively digests the C-terminal products. JMJD5-deficient fibroblasts exhibit dramatically increased levels of methylated arginines and histones | Homo sapiens |