Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrosarcoma cell line | high levels of P3H2 mRNA are expressed | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | results identify a role for P3H2 in 3-hydroxylation of non-A1 proline residues in clade A collagen chains | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
P3H2 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | a knockdown of P3H2 protein using RNA interference reduces 3-hydroxylation at Pro-944, Pro-707, and the GPP repeat at the C-terminus of the triple helix but not at Pro-986 of the clade A pNalpha1(II) collagen chain. When P3H2 expression is turned off, 3-hydroxylation at residue Pro-944 in the alpha2(V) chain is lost, and 3Hyp occupancy at Pro-707 in alpha2(V) and alpha2(I) chains is significantly reduced | Rattus norvegicus |