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Literature summary for 1.14.11.7 extracted from

  • Shah, R.; Smith, P.; Purdie, C.; Quinlan, P.; Baker, L.; Aman, P.; Thompson, A.M.; Crook, T.
    The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer (2009), Br. J. Cancer, 100, 1687-1696.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
ectopic expression of P3H2 in cells with silenced endogenous genes Homo sapiens
ectopic expression of P3H3 in cells with silenced endogenous genes Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information ectopic expression of P3H2 in cells with silenced endogenous genes result in suppression of colony growth Homo sapiens
additional information ectopic expression of P3H3 in cells with silenced endogenous genes result in suppression of colony growth Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IVL5 P3H2
-
Homo sapiens Q8IVL6 P3H3
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
Leprel1
-
Homo sapiens
Leprel2
-
Homo sapiens
P3H2
-
Homo sapiens
P3H3
-
Homo sapiens
prolyl 3-hydroxylase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the expression of P3H2 , or Leprel1, but not of P3H1 or Leprecan, is specifically downregulated in breast cancer by abberrant CpG methylation in the 5' regulatory sequences of the genes. Methylation of P3H2 is strongly associated with estrogen-receptor-positive breast cancers down
Homo sapiens the expression of P3H3, or Leprel2, but not of P3H1 or Leprecan, is specifically downregulated in breast cancer by abberrant CpG methylation in the 5' regulatory sequences of the genes. Methylation of P3H3 is not associated with estrogen-receptor-positive breast cancers, while P3H3 isassociated with higher tumour grade and Nottingham prognostic index down

General Information

General Information Comment Organism
malfunction epigenetic inactivation of the enzyme in human cancer Homo sapiens
physiological function the enzyme acts as a tumor suppressor Homo sapiens
physiological function the enzyme acts as a tumor suppressor, with P3H2 being a specific breast-cancer tumour suppressor Homo sapiens