Cloned (Comment) | Organism |
---|---|
ectopic expression of P3H2 in cells with silenced endogenous genes | Homo sapiens |
ectopic expression of P3H3 in cells with silenced endogenous genes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | ectopic expression of P3H2 in cells with silenced endogenous genes result in suppression of colony growth | Homo sapiens |
additional information | ectopic expression of P3H3 in cells with silenced endogenous genes result in suppression of colony growth | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IVL5 | P3H2 | - |
Homo sapiens | Q8IVL6 | P3H3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Leprel1 | - |
Homo sapiens |
Leprel2 | - |
Homo sapiens |
P3H2 | - |
Homo sapiens |
P3H3 | - |
Homo sapiens |
prolyl 3-hydroxylase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the expression of P3H2 , or Leprel1, but not of P3H1 or Leprecan, is specifically downregulated in breast cancer by abberrant CpG methylation in the 5' regulatory sequences of the genes. Methylation of P3H2 is strongly associated with estrogen-receptor-positive breast cancers | down |
Homo sapiens | the expression of P3H3, or Leprel2, but not of P3H1 or Leprecan, is specifically downregulated in breast cancer by abberrant CpG methylation in the 5' regulatory sequences of the genes. Methylation of P3H3 is not associated with estrogen-receptor-positive breast cancers, while P3H3 isassociated with higher tumour grade and Nottingham prognostic index | down |
General Information | Comment | Organism |
---|---|---|
malfunction | epigenetic inactivation of the enzyme in human cancer | Homo sapiens |
physiological function | the enzyme acts as a tumor suppressor | Homo sapiens |
physiological function | the enzyme acts as a tumor suppressor, with P3H2 being a specific breast-cancer tumour suppressor | Homo sapiens |