Liang, C.; Hsu, P.; Chou, D.; Pan, C.; Wang, L.; Huang, W.; Tsai, M.; Lo, W.
The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1 (2011), Nucleic Acids Res., 39, 4151-4165 .
No PubMed abstract available
Protein Variants
Protein Variants |
Comment |
Organism |
H235A |
catalytically deficient mutant |
Saccharomyces cerevisiae |
Organism
Organism |
UniProt |
Comment |
Textmining |
Saccharomyces cerevisiae |
P39956 |
- |
- |
Posttranslational Modification
Posttranslational Modification |
Comment |
Organism |
phosphoprotein |
phosphorylation of Rph1 is required for efficient PHR1 expression and the dissociation of Rph1 |
Saccharomyces cerevisiae |
Synonyms
Synonyms |
Comment |
Organism |
KDM4 |
- |
Saccharomyces cerevisiae |
Rph1 |
- |
Saccharomyces cerevisiae |
General Information
General Information |
Comment |
Organism |
physiological function |
overexpression of Rph1 reduces the expression of photoreactivation gene PHR1 and increases UV sensitivity. Rph1 is associated at the upstream repression sequence of PHR1 through zinc-finger domains and is dissociated after UV irradiation. Overexpression of Rph1 and H3K36A mutant reduces histone acetylation at the URS. Protein Rad53 acts as an upstream regulator of Rph1 and dominates the phosphorylation of Rph1 that is required for efficient PHR1 expression and the dissociation of Rph1 |
Saccharomyces cerevisiae |