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Literature summary for 1.14.11.69 extracted from

  • Klose, R.J.; Yamane, K.; Bae, Y.; Zhang, D.; Erdjument-Bromage, H.; Tempst, P.; Wong, J.; Zhang, Y.
    The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36 (2006), Nature, 442, 312-316 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expresssion in NIH3T3 and HEK293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 Homo sapiens
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 a [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75164
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Homo sapiens a [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
additional information JHDM3A removes the me3 group from modified H3 lysine 9 (H3K9) and H3 lysine 36 (H3K36) Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
JHDM3A
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 Homo sapiens

General Information

General Information Comment Organism
physiological function overexpression of JHDM3A abrogates recruitment of HP1 (heterochromatin protein 1) to heterochromatin. Knockdown of JHDM3A leads to increased levels of H3K9 methylation and upregulation of JHDM3A target gene ASCL2 Homo sapiens