Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.69 extracted from

  • Liang, C.Y.; Wang, L.C.; Lo, W.S.
    Dissociation of the H3K36 demethylase Rph1 from chromatin mediates derepression of environmental stress-response genes under genotoxic stress in Saccharomyces cerevisiae (2013), Mol. Biol. Cell, 24, 3251-3262 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.69

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Saccharomyces cerevisiae 5634
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P39956
-
-

Synonyms

Synonyms Comment Organism
Rph1
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function Rph1 is mainly a transcriptional repressor, more than 75% of Rph1-regulated genes show increased expression in the Rph1-deletion mutant. The binding motif 5'-CCCCTWA-3' is overrepresented in the promoters of Rph1-repressed genes. A significant proportion of Rph1-regulated genes respond to DNA damage and environmental stress. Rph1 is a labile protein, and Rad53 negatively modulates Rph1 protein level. The JmjN domain is important in maintaining protein stability and the repressive effect of Rph1 Saccharomyces cerevisiae