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Literature summary for 1.14.11.69 extracted from

  • Lin, C.H.; Paulson, A.; Abmayr, S.M.; Workman, J.L.
    HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels (2012), PLoS ONE, 7, e39758.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
HP1a HP1a targets the H3K36 demethylase dKDM4A to heterochromatic genes, it is required for dKDM4A-mediated H3K36me3 demethylation at a subset of heterochromatic genes. Demethylation activity of dKDM4A at euchromatin is independent of HP1a targeting Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
gene dkdm4a, expression of FLAG-tagged wild-type and V423A mutant enzymes Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information generation of dkdm4a mutant embryos, the dkdm4a allele contains a P-element inserted within the first exon of the gene and abrogates dKDM4A transcription Drosophila melanogaster
V423A site-directed mutagenesis, the point mutation at the central valine of PxVxL motif disrupts the interaction between dKDM4A and HP1a in vitro Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Drosophila melanogaster 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 Drosophila melanogaster
-
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
gene dkdm4a
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2
-
Drosophila melanogaster histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
H3K36 demethylase
-
Drosophila melanogaster
KDM4A
-
Drosophila melanogaster
KDM4A demethylase
-
Drosophila melanogaster

General Information

General Information Comment Organism
physiological function dKDM4A demethylase activity regulates eu- and heterochromatic genes Drosophila melanogaster