Activating Compound | Comment | Organism | Structure |
---|---|---|---|
HP1a | HP1a targets the H3K36 demethylase dKDM4A to heterochromatic genes, it is required for dKDM4A-mediated H3K36me3 demethylation at a subset of heterochromatic genes. Demethylation activity of dKDM4A at euchromatin is independent of HP1a targeting | Drosophila melanogaster |
Cloned (Comment) | Organism |
---|---|
gene dkdm4a, expression of FLAG-tagged wild-type and V423A mutant enzymes | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of dkdm4a mutant embryos, the dkdm4a allele contains a P-element inserted within the first exon of the gene and abrogates dKDM4A transcription | Drosophila melanogaster |
V423A | site-directed mutagenesis, the point mutation at the central valine of PxVxL motif disrupts the interaction between dKDM4A and HP1a in vitro | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Drosophila melanogaster | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 | Drosophila melanogaster | - |
histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
gene dkdm4a | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 | - |
Drosophila melanogaster | histone H3-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H3K36 demethylase | - |
Drosophila melanogaster |
KDM4A | - |
Drosophila melanogaster |
KDM4A demethylase | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
physiological function | dKDM4A demethylase activity regulates eu- and heterochromatic genes | Drosophila melanogaster |