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Literature summary for 1.14.11.68 extracted from

  • Lee, M.G.; Villa, R.; Trojer, P.; Norman, J.; Yan, K.P.; Reinberg, D.; Di Croce, L.; Shiekhattar, R.
    Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination (2007), Science, 318, 447-450 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Homo sapiens

Protein Variants

Protein Variants Comment Organism
E1148A mutation in the catalytic JmjC-domain of UTX, abrogates enzymatic activity Homo sapiens
H1146A mutation in the catalytic JmjC-domain of UTX, abrogates enzymatic activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15550 isoform Utx
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information monomethylated histone H3K27 is a poor substrate. No substrates: methylated histone residues H3K4, H3K9, H3K36, H3K79, and H4K20 Homo sapiens ?
-
?
[histone H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2
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Homo sapiens [histone H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2
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Homo sapiens [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2
-
Homo sapiens [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2
-
?

General Information

General Information Comment Organism
physiological function UTX occupies the promoters of HOX gene clusters and regulates their transcriptional output by modulating the recruitment of polycomb repressive complex 1 and the monoubiquitination of histone H2A. UTX associates with mixed-lineage leukemia 2/3 complexes, and during retinoic acid signaling events, the recruitment of the UTX complex to HOX genes results in H3K27 demethylation and a concomitant methylation of H3K4 Homo sapiens