Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E1148A | mutation in the catalytic JmjC-domain of UTX, abrogates enzymatic activity | Homo sapiens |
H1146A | mutation in the catalytic JmjC-domain of UTX, abrogates enzymatic activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15550 | isoform Utx | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | monomethylated histone H3K27 is a poor substrate. No substrates: methylated histone residues H3K4, H3K9, H3K36, H3K79, and H4K20 | Homo sapiens | ? | - |
? | |
[histone H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2 | - |
Homo sapiens | [histone H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2 | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | UTX occupies the promoters of HOX gene clusters and regulates their transcriptional output by modulating the recruitment of polycomb repressive complex 1 and the monoubiquitination of histone H2A. UTX associates with mixed-lineage leukemia 2/3 complexes, and during retinoic acid signaling events, the recruitment of the UTX complex to HOX genes results in H3K27 demethylation and a concomitant methylation of H3K4 | Homo sapiens |