Any feedback?
Literature summary for 1.14.11.68 extracted from
- H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts (2013), PLoS One, 8, e72689 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q5NCY0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spermatogonium | spermatogonial stem cell | Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | histone H3K27 demethylase JMJD3 regulates the fragmentation of spermatogonial cysts. Down-regulation of Jmjd3 in spermatogonial stem cells promotes an increase in undifferentiated spermatogonia but does not affect their differentiation. Germ cell-specific Jmjd3 null male mice have larger testes and sire offspring for a longer period compared to controls. Jmjd3 deficiency induces frequent fragmentation of spermatogonial cysts by abscission of intercellular bridges | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
