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Literature summary for 1.14.11.68 extracted from

  • Das, N.; Jung, K.; Chai, Y.
    The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells (2010), PLoS ONE, 5, e9913 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine upon exposure of macrophages to Bacillus anthracis, lethal toxin, substantial cell death is induced with a survival rate of around 40%. The expression of Jmjd3 is induced 8fold in intoxication-resistant cells generated by treatment with lipopolysaccharides of RAW 264.7 cells. These intoxication-resistant cell lines are maintained for 8 passages and have a survival rate of around 100% on secondary exposure to lethal toxin and lipopolysaccharides Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q5NCY0 isoform Jmjd3
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Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
JMJD3
-
 Mus musculus
KDM6B
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 Mus musculus