Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GSK-J4 | specific inhibitor, application dramatically suppresses Th17 cell differentiation in vitro | Mus musculus |
Organism | UniProt | Comment | Textmining |
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Mus musculus | Q5NCY0 | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | histone H3 lysine-27 demethylation crucially regulatesT helper cell Th17 differentiation. Activation of naive CD41 T cells immediately induces high expression of Jmjd3. Genetic depletion of Jmjd3 in CD41 T cells specifically impairs Th17 cell differentiation both in vitro and in vivo. Jmjd3-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis. Inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppresses Th17 cell differentiation in vitro. Jmjd3 directly binds to and reduces the level of H3K27 trimethylation (me3) at the genomic sites of Rorc | Mus musculus |