Literature summary for 1.14.11.68 extracted from

Li, Y.; Quan, X.; Li, X.; Pan, Y.; Zhang, T.; Liang, Z.; Wang, Y.
Kdm6A protects against hypoxia-induced cardiomyocyte apoptosis via H3K27me3 demethylation of Ncx gene (2019), J. Cardiovasc. Transl. Res., 12, 488-495 .

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Application

Application	Comment	Organism
medicine	demethylase Kdm6a expression is significantly upregulated in a rat acute myocardial infarction model and in hypoxia induction	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	A0A0G2K6D0	isoform Kdm6a	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiomyocyte	cardiomyocyzes cultured in vitro	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
KDM6A	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	the apoptosis rate of cardiomyocytes is significantly exacerbated when Kdm6a is knocked down. The expression of the Na+/Ca2+ exchanger Ncx is significantly upregulated in cardiomyocytes under hypoxia. Knockdown of Kdm6a downregulates the Ncx expression via enhancing H3K27me3 modification on Ncx gene promoter, and attenuates the intracellular calcium-influx ability in cardiomyocytes as a consequence	Rattus norvegicus

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Release 2023.1 (January 2023)