Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.68 extracted from

  • Chen, Y.; Liu, Z.; Pan, T.; Chen, E.; Mao, E.; Chen, Y.; Tan, R.; Wang, X.; Tian, R.; Liu, J.; Qu, H.
    JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis (2018), Int. Immunopharmacol., 59, 40-46 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene KDM6B, quantitative real-time PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GSK-J4 both the mRNA and protein levels of mPR3 are significantly reduced compared to controls Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine 27 + 2-oxoglutarate + O2 Homo sapiens
-
[histone H3]-N6,N6-dimethyl-L-lysine 27 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 27 + 2-oxoglutarate + O2 Homo sapiens
-
[histone H3]-N6-methyl-L-lysine 27 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15054
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil neutrophil JMJD3 expression is increased in patients with sepsis Homo sapiens
-
THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine 27 + 2-oxoglutarate + O2
-
Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine 27 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 27 + 2-oxoglutarate + O2
-
Homo sapiens [histone H3]-N6-methyl-L-lysine 27 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
histone demethylase
-
Homo sapiens
JMJD3
-
Homo sapiens
KDM6B
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens GSK-J4 reduces both the mRNA and protein levels of mPR3 significantly compared to controls down
Homo sapiens lipopolysaccharide (LPS) induces JMJD3 expression in vitro. Neutrophil JMJD3 expression is increased in patients with sepsis compared to controls up

General Information

General Information Comment Organism
physiological function histone demethylase JMJD3 regulates the expression of neutrophil membrane proteinase 3 (mPR3, EC 3.4.21.76) in lipopolysaccharide-stimulated neutrophils, mostly during the early inflammatory response in sepsis. JMJD3 regulates the expression of mPR3 by changing the level of H3K27me3 in LPS-stimulated neutrophils Homo sapiens