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Literature summary for 1.14.11.68 extracted from

  • De Santa, F.; Totaro, M.G.; Prosperini, E.; Notarbartolo, S.; Testa, G.; Natoli, G.
    The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing (2007), Cell, 130, 1083-1094 .
    View publication on PubMed
Search for more literature for 1.14.11.68

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus exclusivley nuclear localization Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q5NCY0 isoform Jmjd3
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage expressed in macrophages in response to bacterial products and inflammatory cytokines Mus musculus
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RAW-264.7 cell
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2
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 Mus musculus [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
JMJD3
-
 Mus musculus
KDM6B
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 Mus musculus

General Information

General Information Comment Organism
physiological function Jmjd3 is expressed in macrophages in response to bacterial products and inflammatory cytokines. Jmjd3 binds PcG target genes and regulates their H3K27me3 levels and transcriptional activity, the activation of Jmjd3 requires NF-kappaB Mus musculus