Literature summary for 1.14.11.67 extracted from

Guo, L.; Guo, Y.Y.; Li, B.Y.; Peng, W.Q.; Tang, Q.Q.
Histone demethylase KDM5A is transactivated by the transcription factor C/EBPbeta and promotes preadipocyte differentiation by inhibiting Wnt/beta-catenin signaling (2019), J. Biol. Chem., 294, 9642-9654 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q3UXZ9	isoform KDM5A	-

Synonyms

Synonyms	Comment	Organism
KDM5A	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	KDM5A is a target gene of early transcription factorCCAAT/enhancer-binding proteinx02 (C/EBPbeta), required for adipogenesis. C/EBPbeta binds to the KDM5A gene promoter and transactivates its expression	additional information

General Information

General Information	Comment	Organism
physiological function	in a murine 3T3-L1 preadipocyte differentiation model, KDM5A down-regulation inhibits 3T3-L1 preadipocyte differentiation. The KDM5A knockdown significantly upregulates the negative regulator of adipogenesis Wnt6, having increased levels of the H3K4me3 mark on its promoter. WNT6 knockdown significantly rescues adipogenesis inhibited by the KDM5A knockdown. Early transcription factor C/EBPbeta negatively regulates Wnt6 expression by binding to the Wnt6 gene promoter and repressing Wnt6 transcription. KDM5A interacts with C/EBPbeta and their interaction cooperatively inhibits Wnt6 transcription	Mus musculus

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Release 2023.1 (January 2023)