Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.67 extracted from

  • Glanzner, W.G.; Gutierrez, K.; Rissi, V.B.; de Macedo, M.P.; Lopez, R.; Currin, L.; Dicks, N.; Baldassarre, H.; Agellon, L.B.; Bordignon, V.
    Histone lysine demethylases KDM5B and KDM5C modulate genome activation and stability in porcine embryos (2020), Front. Cell Dev. Biol., 8, 151 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.67

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-
Sus scrofa A1YVX4 isoform KDM5C
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Sus scrofa
-

Synonyms

Synonyms Comment Organism
KDM5C
-
 Sus scrofa

General Information

General Information Comment Organism
physiological function attenuation of isoforms KDM5B and KDM5C mRNA hampers embryo development to the blastocyst stage in fertilized, parthenogenetically activated and nuclear transfer embryos. Isoform KDM5B attenuation increases H3K4me2-3 levels on D3 embryos and H3K4 mono-, di- and trimethylation on D5 embryos. KDM5C attenuation increases H3K9me1 on D3 embryos, and H3K9me1 and H3K4me1 on D5 embryos. KDM5B and KDM5C attenuation affects DNA damage response and increases DNA double-strand breaks, and decreases development of UV-irradiated embryos Sus scrofa
physiological function attenuation of isoforms KDM5B and KDM5C mRNA hampers embryo development to the blastocyst stage in fertilized, parthenogenetically activated and nuclear transfer embryos. Isoform KDM5B attenuation increases H3K4me2-3 levels on D3 embryos and H3K4 mono-, di- and trimethylation on D5 embryos.KDM5C attenuation increases H3K9me1 on D3 embryos, and H3K9me1 and H3K4me1 on D5 embryos. KDM5B and KDM5C attenuation affects DNA damage response and increases DNA double-strand breaks, and decreases development of UV-irradiated embryos Sus scrofa