Cloned (Comment) | Organism |
---|---|
expressed in HEK-293T cells and NIH-3T3 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
K667A | inactive | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 | Mus musculus | overall reaction | [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 | Mus musculus | - |
[histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 | Mus musculus | - |
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine4, [histone H3]-N6,N6-dimethyl-L-lysine9, [histone H3]-N6,N6-dimethyl-L-lysine27 and [histone H3]-N6,N6-dimethyl-L-lysine36 | Mus musculus | ? | - |
- |
|
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 | overall reaction | Mus musculus | [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Mus musculus | [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Mus musculus | [histone H3]-L-lysine4 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
amine oxidase (flavin-containing) domain 1 | - |
Mus musculus |
AOF1 | - |
Mus musculus |
histone H3K4 demethylase | - |
Mus musculus |
KDM1B | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | demethylation of histone H3 lysine 4 by the enzyme is critical for establishing the DNA methylation imprints during oogenesis | Mus musculus |