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Literature summary for 1.14.11.67 extracted from

  • Ciccone, D.N.; Su, H.; Hevi, S.; Gay, F.; Lei, H.; Bajko, J.; Xu, G.; Li, E.; Chen, T.
    KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints (2009), Nature, 461, 415-418 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells and NIH-3T3 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
K667A inactive Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Mus musculus overall reaction [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine4, [histone H3]-N6,N6-dimethyl-L-lysine9, [histone H3]-N6,N6-dimethyl-L-lysine27 and [histone H3]-N6,N6-dimethyl-L-lysine36 Mus musculus ?
-
-
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 overall reaction Mus musculus [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
amine oxidase (flavin-containing) domain 1
-
Mus musculus
AOF1
-
Mus musculus
histone H3K4 demethylase
-
Mus musculus
KDM1B
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mus musculus

General Information

General Information Comment Organism
physiological function demethylation of histone H3 lysine 4 by the enzyme is critical for establishing the DNA methylation imprints during oogenesis Mus musculus