Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | Mus musculus | - |
[histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 | Mus musculus | - |
[histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 | Mus musculus | - |
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Mus musculus | [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Mus musculus | [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Mus musculus | [histone H3]-L-lysine4 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H3K4 demethylase | - |
Mus musculus |
histone 3 lysine 4 demethylase | - |
Mus musculus |
KDM5B | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme depletion results in a widespread redistribution and disorganization of nucleosomes in a sequence-dependent manner | Mus musculus |
physiological function | the enzyme plays a role in regulating nucleosome positioning in embryonic stem cells | Mus musculus |