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Literature summary for 1.14.11.67 extracted from

  • Kurup, J.; Campeanu, I.; Kidder, B.
    Contribution of H3K4 demethylase KDM5B to nucleosome organization in embryonic stem cells revealed by micrococcal nuclease sequencing (2019), Epigenetics Chromatin, 12, 20 .
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-L-lysine4 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
H3K4 demethylase
-
Mus musculus
histone 3 lysine 4 demethylase
-
Mus musculus
KDM5B
-
Mus musculus

General Information

General Information Comment Organism
malfunction enzyme depletion results in a widespread redistribution and disorganization of nucleosomes in a sequence-dependent manner Mus musculus
physiological function the enzyme plays a role in regulating nucleosome positioning in embryonic stem cells Mus musculus