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Literature summary for 1.14.11.67 extracted from

  • Iwase, S.; Lan, F.; Bayliss, P.; de la Torre-Ubieta, L.; Huarte, M.; Qi, H.H.; Whetstine, J.R.; Bonni, A.; Roberts, T.M.; Shi, Y.
    The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases (2007), Cell, 128, 1077-1088 .
    View publication on PubMed
Search for more literature for 1.14.11.67

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
A388P the mutant shows 14.4% of wild type activity with [histone H3]-N6,N6-dimethyl-L-lysine4 and 45.1% of wild type activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine4 Homo sapiens
F642L the mutant shows 40.1% of wild type activity with [histone H3]-N6,N6-dimethyl-L-lysine4 and 71.6% of wild type activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine4 Homo sapiens
H514A the mutant shows no activity with [histone H3]-N6,N6-dimethyl-L-lysine4 and 2.0% of wild type activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine4 Homo sapiens
L731F the mutant shows 37.2% of wild type activity with [histone H3]-N6,N6-dimethyl-L-lysine4 and 48.1% of wild type activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine4 Homo sapiens
Y751C the mutant shows 51.4% of wild type activity with [histone H3]-N6,N6-dimethyl-L-lysine4 and 56.6% of wild type activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine4 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Homo sapiens overall reaction [histone H3]-N6-methyl-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
FLAG M2 affinity gel chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme does not demethylate [histone H3]-N6-methyl-L-lysine4 Homo sapiens ?
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 overall reaction Homo sapiens [histone H3]-N6-methyl-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
JARID1C
-
 Homo sapiens
SMCX
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme plays a role in neuronal survival and dendritic development Homo sapiens