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Literature summary for 1.14.11.67 extracted from

  • Lloret-Llinares, M.; Carre, C.; Vaquero, A.; de Olano, N.; Azorin, F.
    Characterization of Drosophila melanogaster JmjC+N histone demethylases (2008), Nucleic Acids Res., 36, 2852-2863 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene CG3654, sequence comparisons, recombinant overexpression of FLAG-tagged enzyme in S2 cells. Overexpression experiments, performed both in S2 cells and flies, fail to detect any demethylase activity of dJARID2/CG3654 on H3K4me3, H3K9me3, H3K27me3, H3K36me3 and H4K20me3 Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information GH09982 (CG3654) corresponds to a truncated form missing part of the N-terminal region but carrying the complete C-terminal part containing the JmjN, JmjC and ARID domains (amino acid positions 1521 to 2351). Overexpression of CG3654 shows no significant effect on the levels of H3K4me3, H3K9me3, H3K27me3, H3K36me3 and H4K20me3 Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VT00
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Source Tissue

Source Tissue Comment Organism Textmining
larva
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 Drosophila melanogaster
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salivary gland
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 Drosophila melanogaster
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Synonyms

Synonyms Comment Organism
CG3654
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 Drosophila melanogaster
dJARID2
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 Drosophila melanogaster
dJARID2/CG3654
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 Drosophila melanogaster
GH09982
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 Drosophila melanogaster
Jarid2
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 Drosophila melanogaster

General Information

General Information Comment Organism
evolution the enzyme belongs to the JARID family. JARID proteins contain, in addition to the JmjN and JmjC domains, ARID and C5HC2-zinc finger domains, which mediate DNA binding. JARID proteins are, in turn, divided into two subgroups according to the presence, JARID1, or not, JARID2, of chromatin-binding PHD domains. CG3654 is the structural homologue of mammalian JARID2, as it does not contain any chromatin-binding domains. In this case, however, identity is lower (15%) and, in addition, CG3654 is missing the C5HC2-zinc finger domain present in mammalian JARID2 Drosophila melanogaster
additional information overexpression of CG3654 shows no significant effect on the levels of H3K4me3, H3K9me3, H3K27me3, H3K36me3 and H4K20me3 Drosophila melanogaster
physiological function methylation of H3K4 prevents spreading of heterochromatin. Both H3K36 and H3K4 methylation associate to actively transcribed genes, suggesting that gene activity is a main determinant to delimit hetero- and euchromatic territories. H3K4me3 is an epigenetic mark that correlates with transcriptionally active genes Drosophila melanogaster