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Literature summary for 1.14.11.67 extracted from

  • Soloveychik, M.; Xu, M.; Zaslaver, O.; Lee, K.; Narula, A.; Jiang, R.; Rosebrock, A.P.; Caudy, A.A.; Meneghini, M.D.
    Mitochondrial control through nutritionally regulated global histone H3 lysine-4 demethylation (2016), Sci. Rep., 6, 37942 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.67

Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme mutant Jhd2DELTA MSY724 cells Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatin
-
 Saccharomyces cerevisiae 785
-
nucleus
-
 Saccharomyces cerevisiae 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for catalysis Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Saccharomyces cerevisiae
-
 histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P47156
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Saccharomyces cerevisiae histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
histone H3 lysine-4 demethylase
-
 Saccharomyces cerevisiae
Jhd2
-
 Saccharomyces cerevisiae
Jumonji demethylase
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
evolution Jhd2 belongs to an expansive protein family distinguished by the presence of a JmjC domain. The JmjC domain, initially identified in the C-terminal region of the mouse Jumonji protein, mediates the demethylation of histone lysine residues Saccharomyces cerevisiae
malfunction mutant jhd2DELTA causes only limited gene expression defects in fermenting cells. Mutnat jhd2DELTA causes increased accumulation of the ETC components Cox2 and Sdh3, but not of the mitochondrial membrane proteins Por1 and Tim23. SDH3 mRNA is almost 2fold upregulated in jhd2DELTA Saccharomyces cerevisiae
metabolism yeast possesses solitary H3K4 methyltransferase and demethylase enzymes Saccharomyces cerevisiae
physiological function Saccharomyces cerevisiae Jumonji demethylase Jhd2 opposes the accumulation of H3K4me3 in fermenting cells only when they are nutritionally manipulated to contain an elevated 2-oxoglutarate/succinate ratio. Jhd2 opposes H3K4me3 in respiratory cells that do not exhibit such an elevated 2-oxoglutarate/succinate ratio. JHD2 restrains respiration in nonfermentable growth conditions. Enzyme JHD2 restricts mitochondrial respiratory capacity in cells grown in non-fermentable carbon in an H3K4me-dependent manner. JHD2 limits yeast proliferative capacity under physiologically challenging conditions as measured by both replicative lifespan and colony growth on non-fermentable carbon. JHD2's impact on nutrient response may reflect an ancestral role of its gene family in mediating mitochondrial regulation. The JmjC domain mediates the demethylation of histone lysine residues. Nutritional conditions impact Jhd2 control of H3K4me3 and gene expression. JHD2 controls mitochondrial respiration through H3K4me Saccharomyces cerevisiae