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Literature summary for 1.14.11.67 extracted from

  • Mariani, L.; Lussi, Y.C.; Vandamme, J.; Riveiro, A.; Salcini, A.E.
    The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1 (2016), Development, 143, 851-863 .
    View publication on PubMed
Search for more literature for 1.14.11.67

Cloned(Commentary)

Cloned (Comment) Organism
gene rbr2, generation of transgenic lines in which RBR-2::GFP expression is driven by the rbr-2 promoter showing that RBR-2 is ubiquitously expressed in embryos and larvae, gene rbr-2 interacts with many neuronal genes, overview Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information generation of a rbr-2(tm3141) mutant, expression of wild-type rbr-2 gene completely rescues the PVQ defects Caenorhabditis elegans

Inhibitors

Inhibitors Comment Organism Structure
NURF-1 an H3K4me3-binding protein and member of the chromatin-remodeling complex NURF, is required for promoting aberrant wsp-1 transcription in rbr-2 mutants and its ablation restores wild-type expression of wsp-1 and axon guidance Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Caenorhabditis elegans 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Caenorhabditis elegans
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 histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q23541
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-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
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 Caenorhabditis elegans
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larva
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 Caenorhabditis elegans
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additional information RBR-2 is ubiquitously expressed in embryos and larvae Caenorhabditis elegans
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nervous system
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 Caenorhabditis elegans
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
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 Caenorhabditis elegans histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
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 ?

Synonyms

Synonyms Comment Organism
H3K4me3/2 histone demethylase
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 Caenorhabditis elegans
RBR-2
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 Caenorhabditis elegans

General Information

General Information Comment Organism
evolution RBR-2 is the sole homolog of the KDM5 family of H3K4me3/2 demethylases in Caenorhabditis elegans Caenorhabditis elegans
malfunction the dynamic regulation of histone modifications is important for modulating transcriptional programs during development. Aberrant H3K4 methylation is associated with neurological disorders. Loss of rbr-2 results in increased levels of H3K4me3 at the transcriptional start site of wsp-1, with concomitant higher wsp-1 expression responsible for defective axon guidance, overexpression of WSP-1 mimics rbr-2 loss, and its depletion restores normal axon guidance in rbr-2 mutants, phenotypes in rbr-2(tm3141) mutants, overview. Re-expression of WSP-1 in rbr-2/wsp-1 double mutants results in a significant increase of PVQ defects Caenorhabditis elegans
metabolism NURF-1, an H3K4me3-binding protein and member of the chromatin-remodeling complex NURF, is required for promoting aberrant wsp-1 transcription in rbr-2 mutants and its ablation restores wild-type expression of wsp-1 and axon guidance Caenorhabditis elegans
physiological function the H3K4me3/2 histone demethylase RBR-2 is required during embryogenesis in the nervous system to ensure correct axon guidance. RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1. RBR-2 is essential for establishing correct axon guidance of the PVQ neurons during embryonic development, but it does not play any role in its maintenance. Role of rbr-2 in neuronal development, role of H3K4me3 readers in axon patterning, and epigenetic regulation of transcription. RBR-2 is required specifically in the nervous system (F25B3.3 promoter), but its presence in hypodermal cells (dpy-7 promoter) and in muscles(myo-3 promoter) is not essential Caenorhabditis elegans