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Literature summary for 1.14.11.67 extracted from

  • Lee, N.; Erdjument-Bromage, H.; Tempst, P.; Jones, R.S.; Zhang, Y.
    The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3 (2009), Mol. Cell. Biol., 29, 1401-1410.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
ascorbate required Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of Flag-tagged Mrg15, CG13367, and Lid in S2 cells Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus Lid-containing protein complex, which is composed of proteins Lid, Rpd3, CG3815/Drosophila Pf1, CG13367, and Mrg15 Drosophila melanogaster 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster the demethylase activity of Lid is not affected by its association with other proteins, but Lid antagonizes Rpd3 function acting as a positive trancription regulator. Lid inhibits the activity of Rpd3 at an Rpd3 target gene ?
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster
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[histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the demethylase activity of Lid is not affected by its association with other proteins, but Lid antagonizes Rpd3 function acting as a positive trancription regulator. Lid inhibits the activity of Rpd3 at an Rpd3 target gene Drosophila melanogaster ?
-
?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
-
Drosophila melanogaster [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
?

Subunits

Subunits Comment Organism
More Lid is organized in a protein complex, which is composed of proteins Lid, Rpd3, CG3815/Drosophila Pf1, CG13367, and Mrg15, overview Drosophila melanogaster

Synonyms

Synonyms Comment Organism
H3K4 demethylase
-
Drosophila melanogaster
histone H3 lysine 4 demethylase
-
Drosophila melanogaster
Lid
-
Drosophila melanogaster
little imaginal discs
-
Drosophila melanogaster
More the enzyme is a Trithorax group protein belonging to the JmjC domain-containing proteins Drosophila melanogaster

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Drosophila melanogaster

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
assay at Drosophila melanogaster

General Information

General Information Comment Organism
physiological function function of Lid in gene activation, the biochemical activity of this protein entails the removal of a histone mark that is correlated with active transcription Drosophila melanogaster