Literature summary for 1.14.11.67 extracted from

Tahiliani, M.; Mei, P.; Fang, R.; Leonor, T.; Rutenberg, M.; Shimizu, F.; Li, J.; Rao, A.; Shi, Y.
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation (2007), Nature, 447, 601-605.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[histone-H3]-trimethyllysine4 + 2-oxoglutarate + O2	Homo sapiens	RNA-interference-mediated depletion of SMCX increases H3K4 trimethylation at the sodium channel type 2A (SCN2A) and synapsin I (SYN1) promoters. SMCX activity impairs REST-mediated neuronal gene regulation, thereby contributing to SMCX-associated X-linked mental retardation	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P41229	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[histone-H3]-trimethyllysine4 + 2-oxoglutarate + O2	RNA-interference-mediated depletion of SMCX increases H3K4 trimethylation at the sodium channel type 2A (SCN2A) and synapsin I (SYN1) promoters. SMCX activity impairs REST-mediated neuronal gene regulation, thereby contributing to SMCX-associated X-linked mental retardation	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
histone H3K4 demethylase	-	Homo sapiens
SMCX	-	Homo sapiens

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Release 2023.1 (January 2023)