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Literature summary for 1.14.11.67 extracted from
- PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation (2007), Mol. Cell, 25, 801-812.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| full-length Flag-tagged human PLU-1 is expressed in SF9 cells. PLU-1 is overexpressed in U2OS cells | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MCF-7 cell | PLU-1-mediated H3K4 demethylase activity plays an important role in the proliferative capacity of breast cancer cells through repression of tumor suppressor genes, including BRCA1 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [histone-H3]-dimethyllysine4 + 2-oxoglutarate + O2 | recombinant PLU-1 can only demethylate H3K4me3 and H3K4me2 when analyzed in vitro | Homo sapiens | ? | - |
? |  |
| [histone-H3]-trimethyllysine4 + 2-oxoglutarate + O2 | recombinant PLU-1 can only demethylate H3K4me3 and H3K4me2 when analyzed in vitro | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| H3K4 demethylase | - |
Homo sapiens |
| PLU-1 | - |
Homo sapiens |
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