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Literature summary for 1.14.11.66 extracted from

  • Jiang, Y.; Li, C.; Wu, Q.; An, P.; Huang, L.; Wang, J.; Chen, C.; Chen, X.; Zhang, F.; Ma, L.; Liu, S.; He, H.; Xie, S.; Sun, Y.; Liu, H.; Zhan, Y.; Tao, Y.; Liu, Z.; Sun, X.; Hu, Y.; Wang, Q.; Ye, D.; Zhang, J.; Zou, S.; Wang, Y.; Wei, G.; Liu, Y.; Shi, Y.; Eugene Chin, Y.; Hao, Y.; Wang, F.; Zhang, X.
    Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses (2019), Nat. Commun., 10, 2935 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 Mus musculus overall reaction [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 overall reaction Mus musculus [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
KDM2B
-
Mus musculus
Kdm3b
-
Mus musculus
Kdm4c
-
Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme is responsible for histone 3 lysine 9 demethylation at the cyclin E1 promoter, cyclin E1 induction and B cell proliferation Mus musculus