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Literature summary for 1.14.11.66 extracted from

  • Das, N.D.; Choi, M.R.; Jung, K.H.; Park, J.H.; Lee, H.T.; Das, A.; Kim, S.H.; Chai, Y.G.
    Functional analysis of histone demethylase Jmjd2b on lipopolysaccharide-treated murine neural stem cells (NSCs) (2013), Neurotox. Res., 23, 154-165 .
    View publication on PubMed
Search for more literature for 1.14.11.66

Cloned(Commentary)

Cloned (Comment) Organism
gene KDM4B, quantitative real-time RT-PCR expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of Jmjd2b-knockdown (kd) NE-4C cells. Jmjd2b-kd can inhibit the Notch1, IL-1beta, and IL-2 genes by recruiting repressive H3K9me3 to their promoter. attenuation of Jmjd2b by si RNA, increases expression of Jmjd3, the H3K27me3 demethylase, and of Ccl2, overview. Jmjd2b attenuation inhibits the gene expression of p65, inducible nitric oxide synthase, B cell lymphoma 2, and transforming growth factor beta in Jmjd2b-kd NE-4C cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2 Mus musculus
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 [histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 Mus musculus
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 [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q91VY5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
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NE-4C cell
-
 Mus musculus
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neural stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6,N6-dimethyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2
-
 Mus musculus [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
H3K9me2/3 demethylase
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 Mus musculus
histone-3 lysine-9 di-/tri-methyl demethylase
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 Mus musculus
JMJD2B
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 Mus musculus
KDM4B
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus induction of NF-kappaB and Jmjd2b by long-term lipolysaccharide treatment up

General Information

General Information Comment Organism
malfunction attenuation of Jmjd2b by si RNA, increases expression of Jmjd3, the H3K27me3 demethylase, and of Ccl2, overview. Jmjd2b attenuation inhibits the gene expression of p65, inducible nitric oxide synthase, B cell lymphoma 2, and transforming growth factor beta in Jmjd2b-knockdown NE-4C cells. In NE-4C cells, Jmjd2b attenuation alters the expression of different genes including Notch1, Notch2, Efna5, Cyr61, Efnb2, Tgf-b2, Nodal, Nrp2, Cntfr, Plxnc1, Hivep2, Lef1, Gabrb2, Sema3e, Meis1, and Itgb8, which all experiencing downregulation of more than 2fold Mus musculus
physiological function Jmjd2b, histone-3 lysine-9 di-/tri-methyl (H3K9me2/3) demethylase, is functional following lipopolysaccharide (LPS) treatment and is crucial in multiple signaling pathways and biological processes. Jmjd2b specifically targets the trimethylated lysine 9 of histone H3 (H3K9) for demethylation at pericentric heterochromatin and euchromatin. Jmjd2b plays a role in LPS-mediated inflammation, whith an epigenetic regulation in NE-4C cells. Effect of LPS on cell viability and NO production in NE-4C cells, overview Mus musculus