Literature summary for 1.14.11.66 extracted from

Ipenberg, I.; Guttmann-Raviv, N.; Khoury, H.P.; Kupershmit, I.; Ayoub, N.
Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase (2013), J. Biol. Chem., 288, 14681-14687.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of functional doxycycline-inducible EGFP-KDM4B in U2-OSTetON cell line	Homo sapiens

General Stability

General Stability	Organism
the molecular chaperon Hsp90 interacts with and stabilizes KDM4B protein	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	pharmacological inhibition of Hsp90 promotes ubiquitin-dependent proteasomal degradation of KDM4B. Hsp90 inhibition promotes KDM4B degradation and alters the methylation of H3K9	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2	Homo sapiens	-	histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	levels of KDM4B histone demethylase are elevated in different types of cancer cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2	-	Homo sapiens	histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2	-	?

Synonyms

Synonyms	Comment	Organism
KDM4B/JMJD2B histone demethylase	-	Homo sapiens

General Information

General Information	Comment	Organism
evolution	the enzyme belongs to the family of KDM4A-D histone demethylases	Homo sapiens
malfunction	enzyme depletion suppresses tumor formation	Homo sapiens
additional information	the molecular chaperon Hsp90 interacts with and stabilizes KDM4B protein, pharmacological inhibition of Hsp90 promotes ubiquitin-dependent proteasomal degradation of KDM4B, but not of KDM4C, suggesting that the turnover of these demethylases is regulated by distinct mechanisms, degradation is accompanied by increased methylation of H3K9. Hsp90 inhibition promotes KDM4B degradation and alters the methylation of H3K9	Homo sapiens
physiological function	KDM4A-D histone demethylases selectively demethylates H3K9 and H3K36 and is implicated in key cellular processes including DNA damage response, transcription, cell cycle regulation, cellular differentiation, senescence, and carcinogenesis	Homo sapiens

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Release 2023.1 (January 2023)