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Literature summary for 1.14.11.65 extracted from

  • Tateishi, K.; Okada, Y.; Kallin, E.; Zhang, Y.
    Role of Jhdm2a in regulating metabolic gene expression and obesity resistance (2009), Nature, 458, 757-761 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.65

Organism

Organism UniProt Comment Textmining
Mus musculus Q6PCM1
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-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
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 Mus musculus
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liver
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 Mus musculus
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muscle
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 Mus musculus
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Synonyms

Synonyms Comment Organism
JHDM2A
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus Jhdm2a expression is induced by beta-adrenergic stimulation up

General Information

General Information Comment Organism
physiological function Jhdm2a is critically important in regulating the expression of metabolic genes. The loss of Jhdm2a function results in obesity and hyperlipidemia in mice. The loss of Jhdm2a function disrupts beta-adrenergic-stimulated glycerol release and oxygen consumption in brown fat, and decreases fat oxidation and glycerol release in skeletal muscles. Jhdm2a directly regulates peroxisome proliferator-activated receptor alpha (Ppara) and Ucp1 expression. beta-Adrenergic activation-induced binding of Jhdm2a to the PPAR responsive element (PPRE) of the Ucp1 gene decreases levels of H3K9me2 (dimethylation of lysine 9 of histone H3) at the PPRE Mus musculus