Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | Xenopus laevis | overall reaction | a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Xenopus laevis | - |
a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 | Xenopus laevis | - |
a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
additional information | Xenopus laevis | the enzyme KDM3A is associated with Neurog2 protein, but not Ascl1 protein. Neurog2 recruits the enzyme to demethylate [histone H3]-N6,N6-dimethyl-L-lysine9 at the neurod1 promoter | ? | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Xenopus laevis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | overall reaction | Xenopus laevis | a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Xenopus laevis | a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Xenopus laevis | a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
additional information | the enzyme KDM3A is associated with Neurog2 protein, but not Ascl1 protein. Neurog2 recruits the enzyme to demethylate [histone H3]-N6,N6-dimethyl-L-lysine9 at the neurod1 promoter | Xenopus laevis | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
histone H3 lysine 9 demethylase | - |
Xenopus laevis |
Kdm3a | - |
Xenopus laevis |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme depletion results in defective primary neurogenesis in early Xenopus embryos | Xenopus laevis |
physiological function | KDM3A facilitates the Xenopus Neurog2 (regulator of neuronal fate specification and differentiation) chromatin accessibility during neuronal transcription. KDM3A is not required for the transition of naive ectoderm to neural progenitor cells but is essential for primary neuron formation. Neurog2 promotes the removal of the repressive H3K9me2 marks and addition of active histone marks, including H3K27ac and H3K4me3, at the NeuroD1 and Tubb2b promoters, the activity depends on the presence of KDM3A | Xenopus laevis |
physiological function | the enzyme facilitates the Xenopus Neurog2 chromatin accessibility during neuronal transcription. The enzyme is not required for the transition of naive ectoderm to neural progenitor cells but is essential for primary neuron formation | Xenopus laevis |