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Literature summary for 1.14.11.65 extracted from

  • Li, S.; Ali, S.; Duan, X.; Liu, S.; Du, J.; Liu, C.; Dai, H.; Zhou, M.; Zhou, L.; Yang, L.; Chu, P.; Li, L.; Bhatia, R.; Schones, D.; Wu, X.; Xu, H.; Hua, Y.; Guo, Z.; Yang, Y.; Zheng, L.; Shen, B.
    JMJD1B demethylates H4R3me2s and H3K9me2 to facilitate gene expression for development of hematopoietic stem and progenitor cells (2018), Cell Rep., 23, 389-403 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
H1560A/D1562A/H1689A catalytically inactive mutant, carries mutations in the conserved cofactor (Fe2+) binding site Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme additionally mediates arginine demethylation of H4R3me2s and its intermediate, H4R3me1. Demethylation of H4R3me2s and H3K9me2s in promoter regions is correlated with active gene expression Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
JMJD1B
-
 Mus musculus

General Information

General Information Comment Organism
physiological function knockout of JMJD1B blocks demethylation of H4R3me2s and/or H3K9me2 at distinct clusters of genes and impairs the activation of genes important for hematopoietic stem/progenitor cell differentiation and development. JMJD1B-/- mice show defects in hematopoiesis Mus musculus