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Literature summary for 1.14.11.65 extracted from

  • Wellmann, S.; Bettkober, M.; Zelmer, A.; Seeger, K.; Faigle, M.; Eltzschig, H.K.; Buehrer, C.
    Hypoxia upregulates the histone demethylase JMJD1A via HIF-1 (2008), Biochem. Biophys. Res. Commun., 372, 892-897 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y4C1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fetus
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
JMJD1A
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens upregulation of JMJD1A mRNA and protein in cultured human cells exposed to hypoxia or iron scavengers in vitro is abrogated when hypoxia-inducible factor-1 (HIF-1) signaling is blocked by siRNA. A single pivotal hypoxia responsive element in the promoter of the human JMJD1A gene mediates JMJD1A upregulation by hypoxia, iron scavengers, and HIF-1 up

General Information

General Information Comment Organism
physiological function JMJD1A is increased in most tissues of human fetuses in which oxygen supply is low compared to postnatal levels Homo sapiens