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Literature summary for 1.14.11.65 extracted from
- Histone H3K9 demethylase JMJD1A modulates hepatic stellate cells activation and liver fibrosis by epigenetically regulating peroxisome proliferator-activated receptor gamma (2015), FASEB J., 29, 1830-1841 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of wild-type and mutant enzymes | Homo sapiens |
| overexpression of wild-type and mutant enzymes | Rattus norvegicus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | down-regulation of the expression of JMJD1A using small interfering or short hairpin RNAs | Homo sapiens |
| additional information | down-regulation of the expression of JMJD1A using small interfering or short hairpin RNAs | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
| nucleus | - |
Rattus norvegicus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | JMJD1A epigenetically modifies H3K9me2 in the PPARgamma gene locus | ? | - |
? |  |
| additional information | Rattus norvegicus | JMJD1A epigenetically modifies H3K9me2 in the PPARgamma gene locus | ? | - |
? | |
| additional information | Rattus norvegicus Sprague-Dawley | JMJD1A epigenetically modifies H3K9me2 in the PPARgamma gene locus | ? | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | Rattus norvegicus | - |
[histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | Rattus norvegicus Sprague-Dawley | - |
[histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | Rattus norvegicus | - |
[histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | Rattus norvegicus Sprague-Dawley | - |
[histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9Y4C1 | - |
- |
| Rattus norvegicus | Q63679 | - |
- |
| Rattus norvegicus Sprague-Dawley | Q63679 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| LX-2 cell | - |
Homo sapiens | - |
| stellate cell | - |
Homo sapiens | - |
| stellate cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | JMJD1A epigenetically modifies H3K9me2 in the PPARgamma gene locus | Homo sapiens | ? | - |
? | |
| additional information | JMJD1A epigenetically modifies H3K9me2 in the PPARgamma gene locus | Rattus norvegicus | ? | - |
? | |
| additional information | JMJD1A epigenetically modifies H3K9me2 in the PPARgamma gene locus | Rattus norvegicus Sprague-Dawley | ? | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Rattus norvegicus | [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Rattus norvegicus Sprague-Dawley | [histone H3]-N6-methyl-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Rattus norvegicus | [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6-methyl-L-lysine 9 + 2-oxoglutarate + O2 | - |
Rattus norvegicus Sprague-Dawley | [histone H3]-L-lysine 9 + succinate + formaldehyde + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| H3K9 demethylase | - |
Homo sapiens |
| H3K9 demethylase | - |
Rattus norvegicus |
| histone H3K9 demethylase | - |
Homo sapiens |
| histone H3K9 demethylase | - |
Rattus norvegicus |
| JMJD1A | - |
Homo sapiens |
| JMJD1A | - |
Rattus norvegicus |
| Kdm3a | - |
Homo sapiens |
| Kdm3a | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | downregulation of the expression of JMJD1A using small interfering or short hairpin RNAs. JMJD1A knockdown in hepatic stellate cells correlates with reinforced dimethylated lysine in histone H3, H3K9me2, in the PPARgamma gene promoter. JMJD1A downregulation in both mRNA and protein leads to increased expression of fibrosis markers, which can be consistently rescued by JMJD1A overexpression | Rattus norvegicus |
| malfunction | JMJD1A knockdown in hepatic stellate cells correlates with reinforced H3K9me2 in the PPARgamma gene promoter, and its downregulation in both mRNA and protein leads to increased expression of fibrosis markers, which can be consistently rescued by JMJD1A overexpression. Jmjd1a knockdown in situ results in significantly increased expression of alpha-smooth muscle actin and Col1a, strengthened production of collagens, and remarkably enhanced necrosis 4 weeks after treatment. JMJD1A knockdown using si-JMJD1A-1 and si-JMJD1A-2 results in significantly decreased expression of PPARgamma but does not affect the expression of other PPAR signaling members, JMJD1A may modulate PPARgamma expression in liver HSCs in a cell type-specific manner | Homo sapiens |
| metabolism | JMJD1A as an epigenetic regulator that modulates hepatic stellate cell activation and liver fibrosis through targeting PPARgamma gene expression, molecular mechanism, overview | Homo sapiens |
| metabolism | JMJD1A as an epigenetic regulator that modulates hepatic stellate cell activation and liver fibrosis through targeting PPARgamma gene expression, molecular mechanism, overview | Rattus norvegicus |
| physiological function | histone H3K9 demethylase JMJD1A modulates hepatic stellate cells activation and liver fibrosis by epigenetically regulating peroxisome proliferator-activated receptor gamma (PPARgamma), molecular mechanism, overview | Rattus norvegicus |
| physiological function | histone H3K9 demethylase JMJD1A modulates hepatic stellate cells activation and liver fibrosis by epigenetically regulating peroxisome proliferator-activated receptor gamma, molecular mechanism, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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