Cloned (Comment) | Organism |
---|---|
expression of FLAG-tagged wild-type and H190A mutant Jmjd2c in mouse embryonic fibroblasts | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
H190A | inactive mutant | Mus musculus |
additional information | overexpression of wild-type Jmjd2c, but not of mutant H190A, increases the expression of Mdm2 oncogene dependent on its demethylase activity, which leads to the reduction of p53 tumor suppressor gene product in the cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | Mus musculus | Jmjd2c is recruited to the P2 promoter region of Mdm2 gene resulting in demethylation of histone H3 lysine 9, as typically found in actively transcribed genes | [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | - |
Mus musculus | [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | Jmjd2c is recruited to the P2 promoter region of Mdm2 gene resulting in demethylation of histone H3 lysine 9, as typically found in actively transcribed genes | Mus musculus | [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Jmjd2c histone demethylase | - |
Mus musculus |