Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P0C872 | bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | JMJD7 has divalent cation-dependent protease activities that preferentially cleave the tails of histones 2, 3, or 4 containing methylated arginines. After the initial specific cleavage, JMJD7, acting as aminopeptidase, progressively digests the C-terminal products | Mus musculus | ? | - |
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General Information | Comment | Organism |
---|---|---|
physiological function | the content of arginine methylation of both histones H3R2/H4R3 and overall H3/H4 is increased with the knockout of JMJD7, and the colony-forming abilities of JMJD7-deficient MDA-MB-231 cells are greatly decreased | Mus musculus |