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Literature summary for 1.14.11.60 extracted from

  • Rajniak, J.; Giehl, R.; Chang, E.; Murgia, I.; Von Wiren, N.; Sattely, E.
    Biosynthesis of redox-active metabolites in response to iron deficiency in plants (2018), Nat. Chem. Biol., 14, 442-450.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
heterologous-pathway reconstitution in Nicotiana benthamiana Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
scopoletin + 2-oxoglutarate + O2 Arabidopsis thaliana the enzyme is involved in biosynthesis of iron(III)-chelating coumarins in higher plants fraxetin + succinate + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9LE86
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-

Source Tissue

Source Tissue Comment Organism Textmining
root expressed most strongly in the root epidermal layer under iron-deficient conditions Arabidopsis thaliana
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
scopoletin + 2-oxoglutarate + O2 the enzyme is involved in biosynthesis of iron(III)-chelating coumarins in higher plants Arabidopsis thaliana fraxetin + succinate + CO2
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 ?
scopoletin + 2-oxoglutarate + O2
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 Arabidopsis thaliana fraxetin + succinate + CO2
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 ?

Synonyms

Synonyms Comment Organism
At3g12900
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 Arabidopsis thaliana
S8H
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 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana iron-deficiency-dependent upregulation. The iron-deficiency-dependent upregulation is mainly confined to roots up

General Information

General Information Comment Organism
metabolism the enzyme is involved in biosynthesis of iron(III)-chelating coumarins in higher plants. Under iron-deficiency conditions, a branch of the phenylpropanoid pathway consisting of feruloyl-CoA 6'-hydroxylase 1, scopoletin 8-hydroxylase, and CYP82C4 is strongly induced, thus leading to the synthesis of scopoletin and its conversion into redox-active fraxetin and sideretin. In the rhizosphere, the redox-active coumarins act in concert with other components of the strategy I iron acquisition machinery by solubilizing and reducing iron from sparingly available sources Arabidopsis thaliana