Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8K1E6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MEF cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N3-ethylthymidine in mRNA + 2-oxoglutarate + O2 | - |
Mus musculus | thymidine in mRNA + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALKBH3 | - |
Mus musculus |
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | the absence of Alkbh3 does not lead to a statistically significant change in the transcriptional blockage or mutagenic properties of O2-ethyl-deoxythymidine, O4-ethyl-deoxythymidine, N3-carboxymethyl-deoxythymidine, and O4-carboxymethyl-deoxythymidine in mammalian cells. N3-ethyl-deoxythymidine induces a substantially higher degree of A to U mutation (about 31%) in Alkbh3-deficient cells than in the wildtype background. N3-ethyl-deoxythymidine, but not other lesions, can be repaired by Alkbh3 in mammalian cells | Mus musculus |