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Literature summary for 1.14.11.4 extracted from

  • Xu, Y.; Zhang, L.; Wei, Y.; Zhang, X.; Xu, R.; Han, M.; Huang, B.; Chen, A.; Li, W.; Zhang, Q.; Li, G.; Wang, J.; Zhao, P.; Li, X.
    Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion (2017), Oncotarget, 8, 23401-23413 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2 Homo sapiens
-
 [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00469
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[procollagen]-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
PLOD2
-
 Homo sapiens
procollagen-lysine 2-oxoglutarate 5-dioxygenase 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens hypoxia upregulates PLOD2 protein in U87 and U251 human glioma cell lines. siRNA knockdown of endogenous HIF-1alpha or treatment of cells with the HIF-1alpha inhibitor PX-478 largely abolishes the hypoxia-mediated PLOD2 upregulation up
Homo sapiens PLOD2 mRNA is significantly overexpressed in glioblastoma compared to low-grade tumors. High PLOD2 expression is associated with poor prognosis up

General Information

General Information Comment Organism
drug target PLOD2 is a gene of clinical relevance with implications in glioblastoma invasion and treatment strategies. PLOD2 expression is positively correlated with tumor grade and inversely associated with glioblastoma patient prognosis Homo sapiens
malfunction knockdown of PLOD2 in glioma cell lines leads to decreases in migration and invasion under normoxia and hypoxia Homo sapiens
physiological function PLOD2 promotes tissue invasion of human glioma cells Homo sapiens